Browsing School of Biological and Chemical Sciences by Subject "Zebrafish"
Now showing items 1-14 of 14
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Conserved roles for Hnf4 family transcription factors in zebrafish development and intestinal function.
(2022-11-30)Transcription factors play important roles in the development of the intestinal epithelium and its ability to respond to endocrine, nutritional, and microbial signals. Hepatocyte nuclear factor 4 family nuclear receptors ... -
Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly.
(2013-09-17)Centrioles organise centrosomes and template cilia and flagella. Several centriole and centrosome proteins have been linked to microcephaly (MCPH), a neuro-developmental disease associated with small brain size. CPAP (MCPH6) ... -
Digenic inheritance involving a muscle-specific protein kinase and the giant titin protein causes a skeletal muscle myopathy.
(Springer Nature, 2024-03-01)In digenic inheritance, pathogenic variants in two genes must be inherited together to cause disease. Only very few examples of digenic inheritance have been described in the neuromuscular disease field. Here we show that ... -
Disease-Associated Mutations in CEP120 Destabilize the Protein and Impair Ciliogenesis.
(2018-05-29)Ciliopathies are a group of genetic disorders caused by a failure to form functional cilia. Due to a lack of structural information, it is currently poorly understood how ciliopathic mutations affect protein functionality ... -
Gaucher disease protects against tuberculosis.
(2023-02-14)Biallelic mutations in the glucocerebrosidase (GBA1) gene cause Gaucher disease, characterized by lysosomal accumulation of glucosylceramide and glucosylsphingosine in macrophages. Gaucher and other lysosomal diseases occur ... -
mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity.
(2022-09-29)Necrosis of macrophages in the granuloma, the hallmark immunological structure of tuberculosis, is a major pathogenic event that increases host susceptibility. Through a zebrafish forward genetic screen, we identified the ... -
The ontogeny of continuous quantity discrimination in zebrafish larvae (Danio rerio).
(Springer, 2020-04-15)Several studies have investigated the ontogeny of the capacity to discriminate between discrete numerical information in human and non-human animals. Contrarily, less attention has been devoted to the development of the ... -
Size discrimination in adult zebrafish (Danio rerio): Normative data and individual variation.
(2020-01-24)In humans, aging and neurodegenerative diseases have been found to be associated with impairment in both mathematical abilities and estimation of continuous quantities such as size, weight or distance. Zebrafish (Danio ... -
Spinal motor neurons are regenerated after mechanical lesion and genetic ablation in larval zebrafish.
(2016-05-01)In adult zebrafish, relatively quiescent progenitor cells show lesion-induced generation of motor neurons. Developmental motor neuron generation from the spinal motor neuron progenitor domain (pMN) sharply declines at ... -
Total Nucleic Acid Extraction from Single Zebrafish Embryos for Genotyping and RNA-seq.
(Bio-protocol LLC, 2022-01-05)RNA sequencing allows for the quantification of the transcriptome of embryos to investigate transcriptional responses to various perturbations (e.g., mutations, infections, drug treatments). Previous protocols either lack ... -
Transcriptional profiling of zebrafish identifies host factors controlling susceptibility to Shigella flexneri.
(Disease Models & Mechanisms, 2024-01-26)Shigella flexneri is a human-adapted pathovar of Escherichia coli that can invade the intestinal epithelium, causing inflammation and bacillary dysentery. Although an important human pathogen, the host response to S. ...