Show simple item record

dc.contributor.authorAyerbe, Len_US
dc.contributor.authorForgnone, Ien_US
dc.contributor.authorAddo, Jen_US
dc.contributor.authorSiguero, Aen_US
dc.contributor.authorGelati, Sen_US
dc.contributor.authorAyis, Sen_US
dc.date.accessioned2017-10-02T14:38:54Z
dc.date.available2017-09-01en_US
dc.date.issued2018-01-01en_US
dc.date.submitted2017-09-20T13:18:24.327Z
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/26283
dc.description.abstractBACKGROUND: A higher cardiovascular morbidity and mortality has been observed in patients with bipolar disorder (BPD) or schizophrenia, partly due to an increased risk of hypertension (HTN), or a less effective care of it. This systematic review and meta-analysis, presents a critical appraisal and summary of the studies addressing the risk of HTN, or the differences in its care, for those with schizophrenia or BPD. METHODS: Prospective studies were searched in PubMed, Embase, PsycINFO, Scopus, and the Web of Science, from database inception to June 2017. A meta-analysis was undertaken to obtain pooled estimates of the risk of HTN. RESULTS: Five studies reporting the risk of HTN, and five studies presenting differences in its clinical care, were identified. An increased risk of HTN was observed for BPD patients, with an overall Incidence Rate Ratio 1.27(1.15-1.40). The pooled Incidence Rate Ratio of HTN for those with schizophrenia was 0.94 (0.75 - 1.14). A poorer care of HTN (lower rates of screening, prescription, and adherence) was reported in four studies of schizophrenia, and two of BPD patients, compared to people without these conditions. LIMITATIONS: reduced number of studies on risk and care of HTN on patients with BPD or schizophrenia. CONCLUSIONS: Limited evidence suggests that patients with BPD have a higher risk of HTN. Patients with schizophrenia and BPD receive poor care of HTN. Understanding the risk of HTN, and the differences in its care, is essential for clinicians to reduce the cardiovascular morbidity and overall mortality of these patients.en_US
dc.description.sponsorshipLuis Ayerbe is funded by an NIHR Clinical Lectureship. Salma Ayis is funded by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guys and St Thomas NHS Foundation Trust and Kings College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Healthen_US
dc.format.extent665 - 670en_US
dc.languageengen_US
dc.language.isoenen_US
dc.relation.ispartofJ Affect Disorden_US
dc.rights© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBipolar disorderen_US
dc.subjectHealthcare disparitiesen_US
dc.subjectHypertensionen_US
dc.subjectSchizophreniaen_US
dc.subjectSystematic reviewen_US
dc.subjectBipolar Disorderen_US
dc.subjectCausalityen_US
dc.subjectComorbidityen_US
dc.subjectFemaleen_US
dc.subjectHealth Statusen_US
dc.subjectHumansen_US
dc.subjectHypertensionen_US
dc.subjectProspective Studiesen_US
dc.subjectRisk Factorsen_US
dc.subjectSchizophreniaen_US
dc.titleHypertension risk and clinical care in patients with bipolar disorder or schizophrenia; a systematic review and meta-analysis.en_US
dc.typeArticle
dc.identifier.doi10.1016/j.jad.2017.09.002en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/28915505en_US
pubs.notesNot knownen_US
pubs.organisational-group/Queen Mary University of London
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry/Blizard Institute
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry/Blizard Institute/Centre for Primary Care and Public Health
pubs.publication-statusPublisheden_US
pubs.volume225en_US
dcterms.dateAccepted2017-09-02en_US


Files in this item

Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record