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Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci

dc.contributor.authorJones, GTen_US
dc.contributor.authorTromp, Gen_US
dc.contributor.authorKuivaniemi, Hen_US
dc.contributor.authorGretarsdottir, Sen_US
dc.contributor.authorBaas, AFen_US
dc.contributor.authorGiusti, Ben_US
dc.contributor.authorStrauss, Een_US
dc.contributor.authorvan't Hof, FNGen_US
dc.contributor.authorWebb, TRen_US
dc.contributor.authorErdman, Ren_US
dc.contributor.authorRitchie, MDen_US
dc.contributor.authorElmore, JRen_US
dc.contributor.authorVerma, Aen_US
dc.contributor.authorPendergrass, Sen_US
dc.contributor.authorKullo, IJen_US
dc.contributor.authorZy, ZYen_US
dc.contributor.authorPeissig, PLen_US
dc.contributor.authorGottesman, Oen_US
dc.contributor.authorVerma, SSen_US
dc.contributor.authorMalinowski, Jen_US
dc.contributor.authorRasmussen-Torvik, LJen_US
dc.contributor.authorBorthwick, KMen_US
dc.contributor.authorSmelser, DTen_US
dc.contributor.authorCrosslin, DRen_US
dc.contributor.authorde Andrade, Men_US
dc.contributor.authorRyer, EJen_US
dc.contributor.authorMcCarty, CAen_US
dc.contributor.authorBottinger, EPen_US
dc.contributor.authorPacheco, JAen_US
dc.contributor.authorCrawford, DCen_US
dc.contributor.authorCarrell, DSen_US
dc.contributor.authorGerhard, GSen_US
dc.contributor.authorFranklin, DPen_US
dc.contributor.authorCarey, DJen_US
dc.contributor.authorPhillips, VLen_US
dc.contributor.authorWilliams, MJAen_US
dc.contributor.authorWei, Wen_US
dc.contributor.authorBlair, Ren_US
dc.contributor.authorHill, AAen_US
dc.contributor.authorVasudevan, TMen_US
dc.contributor.authorLewis, DRen_US
dc.contributor.authorThomson, IAen_US
dc.contributor.authorKrysa, Jen_US
dc.contributor.authorHill, GBen_US
dc.contributor.authorRoake, Jen_US
dc.contributor.authorMerriman, TRen_US
dc.contributor.authorOszkinis, Gen_US
dc.contributor.authorGalora, Sen_US
dc.contributor.authorSaracini, Cen_US
dc.contributor.authorAbbate, Ren_US
dc.contributor.authorPulli, Ren_US
dc.contributor.authorPratesi, Cen_US
dc.contributor.authorSaratzis, Aen_US
dc.contributor.authorVerissimo, ARen_US
dc.contributor.authorBumpstead, Sen_US
dc.contributor.authorBadger, SAen_US
dc.contributor.authorClough, REen_US
dc.contributor.authorCockerill, Gen_US
dc.contributor.authorHafez, Hen_US
dc.contributor.authorScott, DJAen_US
dc.contributor.authorFuters, TSen_US
dc.contributor.authorRomaine, SPRen_US
dc.contributor.authorBridge, Ken_US
dc.contributor.authorGriffin, KJen_US
dc.contributor.authorBailey, MAen_US
dc.contributor.authorSmith, Aen_US
dc.contributor.authorThompson, MMen_US
dc.contributor.authorvan Bockxmeer, FMen_US
dc.contributor.authorMatthiasson, SEen_US
dc.contributor.authorThorleifsson, Gen_US
dc.contributor.authorThorsteinsdottir, Uen_US
dc.contributor.authorBlankensteijn, JDen_US
dc.contributor.authorTeijink, JAWen_US
dc.contributor.authorWijmenga, Cen_US
dc.contributor.authorde Graaf, Jen_US
dc.contributor.authorKiemeney, LAen_US
dc.contributor.authorLindholt, JSen_US
dc.contributor.authorHughes, Aen_US
dc.contributor.authorBradley, DTen_US
dc.contributor.authorStirrups, Ken_US
dc.contributor.authorGolledge, Jen_US
dc.contributor.authorNorman, PEen_US
dc.contributor.authorPowell, JTen_US
dc.contributor.authorHumphries, SEen_US
dc.contributor.authorHamby, SEen_US
dc.contributor.authorGoodall, AHen_US
dc.contributor.authorNelson, CPen_US
dc.contributor.authorSakalihasan, Nen_US
dc.contributor.authorCourtois, Aen_US
dc.contributor.authorFerrell, REen_US
dc.contributor.authorEriksson, Pen_US
dc.contributor.authorFolkersen, Len_US
dc.contributor.authorFranco-Cereceda, Aen_US
dc.contributor.authorEicher, JDen_US
dc.contributor.authorJohnson, ADen_US
dc.contributor.authorBetsholtz, Cen_US
dc.contributor.authorRuusalepp, Aen_US
dc.contributor.authorFranzen, Oen_US
dc.contributor.authorSchadt, EEen_US
dc.contributor.authorBjorkegren, JLMen_US
dc.contributor.authorLipovich, Len_US
dc.contributor.authorDrolet, AMen_US
dc.contributor.authorVerhoeven, ELen_US
dc.contributor.authorZeebregts, CJen_US
dc.contributor.authorGeelkerken, RHen_US
dc.contributor.authorvan Sambeek, MRen_US
dc.contributor.authorvan Sterkenburg, SMen_US
dc.contributor.authorde Vries, J-Pen_US
dc.contributor.authorStefansson, Ken_US
dc.contributor.authorThompson, JRen_US
dc.contributor.authorde Bakker, PIWen_US
dc.contributor.authorDeloukas, Pen_US
dc.contributor.authorSayers, RDen_US
dc.contributor.authorHarrison, SCen_US
dc.contributor.authorvan Rij, AMen_US
dc.contributor.authorSamani, NJen_US
dc.contributor.authorBown, MJen_US
dc.contributor.authorConsortium, Cen_US
dc.contributor.authorPressure, ICBen_US
dc.date.accessioned2017-05-30T09:22:50Z
dc.date.available2016-11-21en_US
dc.date.issued2017-01-20en_US
dc.date.submitted2017-05-25T11:08:18.892Z
dc.identifier.issn0009-7330en_US
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/23425
dc.description.sponsorshipThe Welcome Trust Case Control Consortium project was funded by the Wellcome Trust (awards 076113 and 085475). The New Zealand project was funded by the Health Research Council of New Zealand (08–75, 14–155). Recruitment of abdominal aortic aneurysm patients and controls in Belgium, Canada, and Pittsburgh, USA, was funded in part by the National Heart, Lung, and Blood Institute, National Institutes of Health (HL064310 and HL044682). The Geisinger sample collection was funded in part by the Pennsylvania Commonwealth Universal Research Enhancement program, the Geisinger Clinical Research Fund, the American Heart Association, and the Ben Franklin Technology Development Fund of Pennsylvania. The Barts and the Leicester Cardiovascular Biomedical Research Units are funded by the National Institute for Health Research. The eMERGE (electronic Medical Records and Genomics) Network is funded by the National Human Genome Research Institute, with additional funding from the National Institute of General Medical Sciences through the following grants: U01HG004438 to Johns Hopkins University; U01HG004424 to The Broad Institute; U01HG004438 to CIDR; U01HG004610 and U01HG006375 to Group Health Cooperative; U01HG004608 to Marshfield Clinic; U01HG006389 to Essentia Institute of Rural Health; U01HG04599 and U01HG006379 to Mayo Clinic; U01HG004609 and U01HG006388 to Northwestern University; U01HG04603 and U01HG006378 to Vanderbilt University; U01HG006385 to the Coordinating Center; U01HG006382 to Geisinger Health System; U01HG006380 to Icahn School of Medicine Mount Sinai. The generation and management of genome-wide association study (GWAS) data for the Rotterdam Study (control samples for the Dutch GWAS) is supported by the Netherlands Organization of Scientific Research (NWO) Investments (175.010.2005.011, 911-03-012). This study is funded by the Research Institute for Diseases in the Elderly (014-93-015; RIDE2), the Netherlands Genomics Initiative/NWO project nr. 050-060-810. The Italian sample collection were funded by grants from Ente Cassa di Risparmio di Firenze to Fiorgen Foundation, Florence, Italy, and from the Italian Ministry of Health. Sample collections from Poland were funded in part by the National Science Centre in Poland (6P05A03921, NN403250440). The Mayo Vascular Disease Biorepository was funded by a Marriot Award for Individualized Medicine and an Award from the Mayo Center of Individualized Medicine. The Vanderbilt data set(s) were obtained from Vanderbilt University Medical Center’s BioVU supported by institutional funding and by the National Center for Research Resources (UL1 RR024975-01, which is now at the National Center for Advancing Translational Sciences, UL1 TR000445-06). The ASAP study (Advanced Study of Aortic Pathology) was supported by the Swedish Research Council, the Swedish Heart-Lung Foundation, the Leducq Foundation (MIBAVA), and a donation by Fredrik Lundberg. S.E. Humphries holds a Chair funded by the British Heart Foundation, and is supported by the British Heart Foundation (BHF; PG08/008) and by the National Institute for Health Research University College London Hospitals Biomedical Research Centre. The Cardiogenics project was supported by the European Union 6th Framework Programme (LSHM-CT-2006–037593). S.C. Harrison was funded by a BHF clinical training fellowship (FS/11/16/28696). The Stockholm-Tartu Atherosclerosis Reverse Network Engineering Task biobank and the generation of the RNASeq data set was funded by Astra-Zeneca Translational Science Centre-Karolinska Institutet, the University of Tartu (SP1GVARENG), the Estonian Research Council (ETF 8853), the Torsten and Ragnar Söderberg Foundation, the Knut and Alice Wallenberg Foundation, the American Heart Association (A14SFRN20840000) and by the National Institute of Health (R01HL71207).en_US
dc.format.extent341 - +en_US
dc.language.isoenen_US
dc.relation.ispartofCIRCULATION RESEARCHen_US
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.
dc.subjectaortic aneurysm, abdominalen_US
dc.subjectcomputational biologyen_US
dc.subjectgeneticsen_US
dc.subjectgenome-wide association studyen_US
dc.subjectmatrix metalloproteinasesen_US
dc.subjectmeta-analysisen_US
dc.titleMeta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Locien_US
dc.typeArticle
dc.rights.holder© 2016 The Authors.
dc.identifier.doi10.1161/CIRCRESAHA.116.308765en_US
pubs.author-urlhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000392226200017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6aen_US
pubs.issue2en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume120en_US


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