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    Standardized Outcomes in Nephrology-Transplantation: A Global Initiative to Develop a Core Outcome Set for Trials in Kidney Transplantation. 
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    • Standardized Outcomes in Nephrology-Transplantation: A Global Initiative to Develop a Core Outcome Set for Trials in Kidney Transplantation.
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    • Centre for Endocrinology
    • Standardized Outcomes in Nephrology-Transplantation: A Global Initiative to Develop a Core Outcome Set for Trials in Kidney Transplantation.
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    Standardized Outcomes in Nephrology-Transplantation: A Global Initiative to Develop a Core Outcome Set for Trials in Kidney Transplantation.

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    Published Version (290.4Kb)
    Volume
    2
    Pagination
    e79 - ?
    DOI
    10.1097/TXD.0000000000000593
    Journal
    Transplant Direct
    Issue
    6
    ISSN
    2373-8731
    Metadata
    Show full item record
    Abstract
    BACKGROUND: Although advances in treatment have dramatically improved short-term graft survival and acute rejection in kidney transplant recipients, long-term graft outcomes have not substantially improved. Transplant recipients also have a considerably increased risk of cancer, cardiovascular disease, diabetes, and infection, which all contribute to appreciable morbidity and premature mortality. Many trials in kidney transplantation are short-term, frequently use unvalidated surrogate endpoints, outcomes of uncertain relevance to patients and clinicians, and do not consistently measure and report key outcomes like death, graft loss, graft function, and adverse effects of therapy. This diminishes the value of trials in supporting treatment decisions that require individual-level multiple tradeoffs between graft survival and the risk of side effects, adverse events, and mortality. The Standardized Outcomes in Nephrology-Transplantation initiative aims to develop a core outcome set for trials in kidney transplantation that is based on the shared priorities of all stakeholders. METHODS: This will include a systematic review to identify outcomes reported in randomized trials, a Delphi survey with an international multistakeholder panel (patients, caregivers, clinicians, researchers, policy makers, members from industry) to develop a consensus-based prioritized list of outcome domains and a consensus workshop to review and finalize the core outcome set for trials in kidney transplantation. CONCLUSIONS: Developing and implementing a core outcome set to be reported, at a minimum, in all kidney transplantation trials will improve the transparency, quality, and relevance of research; to enable kidney transplant recipients and their clinicians to make better-informed treatment decisions for improved patient outcomes.
    Authors
    Tong, A; Budde, K; Gill, J; Josephson, MA; Marson, L; Pruett, TL; Reese, PP; Rosenbloom, D; Rostaing, L; Warrens, AN
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/15116
    Collections
    • Centre for Endocrinology [517]
    Language
    eng
    Licence information
    The final publication is available at http://journals.lww.com/transplantationdirect/Fulltext/2016/06000/Standardized_Outcomes_in.10.aspx
    Copyright statements
    © 2016 The Authors. Published by Wolters Kluwer Health, Inc
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