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A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

dc.contributor.authorScott, RAen_US
dc.contributor.authorFreitag, DFen_US
dc.contributor.authorLi, Len_US
dc.contributor.authorChu, AYen_US
dc.contributor.authorSurendran, Pen_US
dc.contributor.authorYoung, Ren_US
dc.contributor.authorGrarup, Nen_US
dc.contributor.authorStancakova, Aen_US
dc.contributor.authorChen, Yen_US
dc.contributor.authorVarga, TVen_US
dc.contributor.authorYaghootkar, Hen_US
dc.contributor.authorLuan, Jen_US
dc.contributor.authorZhao, JHen_US
dc.contributor.authorWillems, SMen_US
dc.contributor.authorWessel, Jen_US
dc.contributor.authorWang, Sen_US
dc.contributor.authorMaruthur, Nen_US
dc.contributor.authorMichailidou, Ken_US
dc.contributor.authorPirie, Aen_US
dc.contributor.authorvan der Lee, SJen_US
dc.contributor.authorGillson, Cen_US
dc.contributor.authorAl Olama, AAen_US
dc.contributor.authorAmouyel, Pen_US
dc.contributor.authorArriola, Len_US
dc.contributor.authorArveiler, Den_US
dc.contributor.authorAviles-Olmos, Ien_US
dc.contributor.authorBalkau, Ben_US
dc.contributor.authorBarricarte, Aen_US
dc.contributor.authorBarroso, Ien_US
dc.contributor.authorGarcia, SBen_US
dc.contributor.authorBis, JCen_US
dc.contributor.authorBlankenberg, Sen_US
dc.contributor.authorBoehnke, Men_US
dc.contributor.authorBoeing, Hen_US
dc.contributor.authorBoerwinkle, Een_US
dc.contributor.authorBorecki, IBen_US
dc.contributor.authorBork-Jensen, Jen_US
dc.contributor.authorBowden, Sen_US
dc.contributor.authorCaldas, Cen_US
dc.contributor.authorCaslake, Men_US
dc.contributor.authorCupples, LAen_US
dc.contributor.authorCruchaga, Cen_US
dc.contributor.authorCzajkowski, Jen_US
dc.contributor.authorden Hoed, Men_US
dc.contributor.authorDunn, JAen_US
dc.contributor.authorEarl, HMen_US
dc.contributor.authorEhret, GBen_US
dc.contributor.authorFerrannini, Een_US
dc.contributor.authorFerrieres, Jen_US
dc.contributor.authorFoltynie, Ten_US
dc.contributor.authorFord, Ien_US
dc.contributor.authorForouhi, NGen_US
dc.contributor.authorGianfagna, Fen_US
dc.contributor.authorGonzalez, Cen_US
dc.contributor.authorGrioni, Sen_US
dc.contributor.authorHiller, Len_US
dc.contributor.authorJansson, J-Hen_US
dc.contributor.authorJorgensen, MEen_US
dc.contributor.authorJukema, JWen_US
dc.contributor.authorKaaks, Ren_US
dc.contributor.authorKee, Fen_US
dc.contributor.authorKerrison, NDen_US
dc.contributor.authorKey, TJen_US
dc.contributor.authorKontto, Jen_US
dc.contributor.authorKote-Jarai, Zen_US
dc.contributor.authorKraja, ATen_US
dc.contributor.authorKuulasmaa, Ken_US
dc.contributor.authorKuusisto, Jen_US
dc.contributor.authorLinneberg, Aen_US
dc.contributor.authorLiu, Cen_US
dc.contributor.authorMarenne, Gen_US
dc.contributor.authorMohlke, KLen_US
dc.contributor.authorMorris, APen_US
dc.contributor.authorMuir, Ken_US
dc.contributor.authorMueller-Nurasyid, Men_US
dc.contributor.authorMunroe, PBen_US
dc.contributor.authorNavarro, Cen_US
dc.contributor.authorNielsen, SFen_US
dc.contributor.authorNilsson, PMen_US
dc.contributor.authorNordestgaard, BGen_US
dc.contributor.authorPackard, CJen_US
dc.contributor.authorPalli, Den_US
dc.contributor.authorPanico, Sen_US
dc.contributor.authorPeloso, GMen_US
dc.contributor.authorPerola, Men_US
dc.contributor.authorPeters, Aen_US
dc.contributor.authorPoole, CJen_US
dc.contributor.authorQuiros, JRen_US
dc.contributor.authorRolandsson, Oen_US
dc.contributor.authorSacerdote, Cen_US
dc.contributor.authorSalomaa, Ven_US
dc.contributor.authorSanchez, M-Jen_US
dc.contributor.authorSattar, Nen_US
dc.contributor.authorSharp, SJen_US
dc.contributor.authorSims, Ren_US
dc.contributor.authorSlimani, Nen_US
dc.contributor.authorSmith, JAen_US
dc.contributor.authorThompson, DJen_US
dc.contributor.authorTrompet, Sen_US
dc.contributor.authorTumino, Ren_US
dc.contributor.authorvan der A, DLen_US
dc.contributor.authorvan der Schouw, YTen_US
dc.contributor.authorVirtamo, Jen_US
dc.contributor.authorWalker, Men_US
dc.contributor.authorWalter, Ken_US
dc.contributor.authorAbraham, JEen_US
dc.contributor.authorAmundadottir, LTen_US
dc.contributor.authorAponte, JLen_US
dc.contributor.authorButterworth, Aen_US
dc.contributor.authorDupuis, Jen_US
dc.contributor.authorEaston, DFen_US
dc.contributor.authorEeles, RAen_US
dc.contributor.authorErdmann, Jen_US
dc.contributor.authorFranks, PWen_US
dc.contributor.authorFrayling, TMen_US
dc.contributor.authorHansen, Ten_US
dc.contributor.authorHowson, JMMen_US
dc.contributor.authorJorgensen, Ten_US
dc.contributor.authorKooner, Jen_US
dc.contributor.authorLaakso, Men_US
dc.contributor.authorLangenberg, Cen_US
dc.contributor.authorMcCarthy, MIen_US
dc.contributor.authorPankow, JSen_US
dc.contributor.authorPedersen, Oen_US
dc.contributor.authorRiboli, Een_US
dc.contributor.authorRotter, JIen_US
dc.contributor.authorSaleheen, Den_US
dc.contributor.authorSamani, NJen_US
dc.contributor.authorSchunkert, Hen_US
dc.contributor.authorVollenweider, Pen_US
dc.contributor.authorO'Rahilly, Sen_US
dc.contributor.authorDeloukas, Pen_US
dc.contributor.authorDanesh, Jen_US
dc.contributor.authorGoodarzi, MOen_US
dc.contributor.authorKathiresan, Sen_US
dc.contributor.authorMeigs, JBen_US
dc.contributor.authorEhm, MGen_US
dc.contributor.authorWareham, NJen_US
dc.contributor.authorWaterworth, DMen_US
dc.contributor.authorConsortium, Cen_US
dc.contributor.authorConsortium, GERAD-ECen_US
dc.contributor.authorGrp, NWen_US
dc.contributor.authorCHARGEen_US
dc.contributor.authorConsortiu, ADGen_US
dc.contributor.authorConsortium, PCCen_US
dc.contributor.authorEuropean, PIICen_US
dc.contributor.authorEPIC-InterActen_US
dc.contributor.authorConsortium, CHARGEen_US
dc.contributor.authorConsortium, CHDEen_US
dc.contributor.authorConsortium, CARDIOGRAMEen_US
dc.date.accessioned2016-06-28T11:40:01Z
dc.date.available2016-05-10en_US
dc.date.issued2016-06-01en_US
dc.date.submitted2016-06-08T17:55:18.782Z
dc.identifier.issn1946-6234en_US
dc.identifier.otherARTN 341ra76en_US
dc.identifier.otherARTN 341ra76en_US
dc.identifier.otherARTN 341ra76en_US
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/13116
dc.description.sponsorshipThe work described in this manuscript was funded, in part, by GSK, and, in part, by the Medical Research Council (MC_UU_12015/1). CHARGE AD analyses were funded by R01 AG033193 (PI Seshadri). ADGC AD analyses were funded by UO1AG032984 (PI Schellenberg). Additional funding sources are outlined in the Supplementary Materials.en_US
dc.relation.ispartofSCIENCE TRANSLATIONAL MEDICINEen_US
dc.rightsThis is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science Translational Medicine vol. 8 no. 341 341ra76 on 01/06/2016, DOI: 10.1126/scitranslmed.aad3744
dc.titleA genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart diseaseen_US
dc.typeArticle
dc.rights.holderCopyright © 2016, American Association for the Advancement of Science
dc.identifier.doi10.1126/scitranslmed.aad3744en_US
pubs.author-urlhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000377443000003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6aen_US
pubs.issue341en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume8en_US


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