A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering.
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AIM: To find new genetic loci associated with statin response, and to investigate the association of a genetic risk score (GRS) with this outcome. PATIENTS & METHODS: In a discovery meta-analysis (five studies, 1991 individuals), we investigated the effects of approximately 50000 single nucleotide polymorphisms on statin response, following up associations with p < 1 × 10(-4) (three independent studies, 5314 individuals). We further assessed the effect of a GRS based on SNPs in ABCG2, LPA and APOE. RESULTS: No new SNPs were found associated with statin response. The GRS was associated with reduced statin response: 0.0394 mmol/l per allele (95% CI: 0.0171-0.0617, p = 5.37 × 10(-4)). CONCLUSION: The GRS was associated with statin response, but the small effect size (˜2% of the average low-density lipoprotein cholesterol reduction) limits applicability.
AuthorsLeusink, M; Maitland-van der Zee, AH; Ding, B; Drenos, F; van Iperen, EP; Warren, HR; Caulfield, MJ; Cupples, LA; Cushman, M; Hingorani, AD; Hoogeveen, RC; Hovingh, GK; Kumari, M; Lange, LA; Munroe, PB; Nyberg, F; Schreiner, PJ; Sivapalaratnam, S; de Bakker, PI; de Boer, A; Keating, BJ; Asselbergs, FW; Onland-Moret, NC
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