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dc.contributor.authorParker, MOen_US
dc.contributor.authorIfe, Den_US
dc.contributor.authorMa, Jen_US
dc.contributor.authorPancholi, Men_US
dc.contributor.authorSmeraldi, Fen_US
dc.contributor.authorStraw, Cen_US
dc.contributor.authorBrennan, CHen_US
dc.date.accessioned2016-06-06T14:18:49Z
dc.date.available2013-09-19en_US
dc.date.issued2013en_US
dc.date.submitted2016-06-04T08:49:40.986Z
dc.identifier.issn1662-5137en_US
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/12692
dc.description.abstractDeficits in impulse control (difficulties in inhibition of a pre-potent response) are fundamental to a number of psychiatric disorders, but the molecular and cellular basis is poorly understood. Zebrafish offer a very useful model for exploring these mechanisms, but there is currently a lack of validated procedures for measuring impulsivity in fish. In mammals, impulsivity can be measured by examining rates of anticipatory responding in the 5-choice serial reaction time task (5-CSRTT), a continuous performance task where the subject is reinforced upon accurate detection of a briefly presented light in one of five distinct spatial locations. This paper describes the development of a fully-integrated automated system for testing impulsivity in adult zebrafish. We outline the development of our image analysis software and its integration with National Instruments drivers and actuators to produce the system. We also describe an initial validation of the system through a one-generation screen of chemically mutagenized zebrafish, where the testing parameters were optimized.en_US
dc.format.extent65 - ?en_US
dc.languageengen_US
dc.language.isoenen_US
dc.relation.ispartofFront Syst Neuroscien_US
dc.rightsCC-BY
dc.subject5-choice serial reaction timeen_US
dc.subjectautomationen_US
dc.subjectimpulse controlen_US
dc.subjectmutagenesisen_US
dc.subjectscreeningen_US
dc.subjectzebrafishen_US
dc.titleDevelopment and automation of a test of impulse control in zebrafish.en_US
dc.typeArticle
dc.rights.holder© 2013 Parker, Ife, Ma, Pancholi, Smeraldi, Straw and Brennan.
dc.identifier.doi10.3389/fnsys.2013.00065en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/24133417en_US
pubs.notesNot knownen_US
pubs.organisational-group/Queen Mary University of London
pubs.organisational-group/Queen Mary University of London/Faculty of Science & Engineering
pubs.organisational-group/Queen Mary University of London/Faculty of Science & Engineering/Biological and Chemical Sciences - Staff
pubs.organisational-group/Queen Mary University of London/Faculty of Science & Engineering/Electronic Engineering and Computer Science - Staff
pubs.organisational-group/Queen Mary University of London/REF
pubs.organisational-group/Queen Mary University of London/REF/REF - UoA 05
pubs.organisational-group/Queen Mary University of London/REF/REF - UoA 11
pubs.publication-statusPublished onlineen_US
pubs.volume7en_US
dcterms.dateAccepted2013-09-19en_US


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