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    Development and automation of a test of impulse control in zebrafish. 
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    Development and automation of a test of impulse control in zebrafish.

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    Published version (3.426Mb)
    Volume
    7
    Pagination
    65 - ?
    DOI
    10.3389/fnsys.2013.00065
    Journal
    Front Syst Neurosci
    ISSN
    1662-5137
    Metadata
    Show full item record
    Abstract
    Deficits in impulse control (difficulties in inhibition of a pre-potent response) are fundamental to a number of psychiatric disorders, but the molecular and cellular basis is poorly understood. Zebrafish offer a very useful model for exploring these mechanisms, but there is currently a lack of validated procedures for measuring impulsivity in fish. In mammals, impulsivity can be measured by examining rates of anticipatory responding in the 5-choice serial reaction time task (5-CSRTT), a continuous performance task where the subject is reinforced upon accurate detection of a briefly presented light in one of five distinct spatial locations. This paper describes the development of a fully-integrated automated system for testing impulsivity in adult zebrafish. We outline the development of our image analysis software and its integration with National Instruments drivers and actuators to produce the system. We also describe an initial validation of the system through a one-generation screen of chemically mutagenized zebrafish, where the testing parameters were optimized.
    Authors
    Parker, MO; Ife, D; Ma, J; Pancholi, M; Smeraldi, F; Straw, C; Brennan, CH
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/12692
    Collections
    • School of Biological and Chemical Sciences [1979]
    Language
    eng
    Licence information
    CC-BY
    Copyright statements
    © 2013 Parker, Ife, Ma, Pancholi, Smeraldi, Straw and Brennan.
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