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Health and population effects of rare gene knockouts in adult humans with related parents

dc.contributor.authorNarasimhan, VMen_US
dc.contributor.authorHunt, KAen_US
dc.contributor.authorMason, Den_US
dc.contributor.authorBaker, CLen_US
dc.contributor.authorKarczewski, KJen_US
dc.contributor.authorBarnes, MERen_US
dc.contributor.authorBarnett, AHen_US
dc.contributor.authorBates, Cen_US
dc.contributor.authorBellary, Sen_US
dc.contributor.authorBockett, NAen_US
dc.contributor.authorGiorda, Ken_US
dc.contributor.authorGriffiths, CJen_US
dc.contributor.authorHemingway, Hen_US
dc.contributor.authorJia, Zen_US
dc.contributor.authorKelly, MAen_US
dc.contributor.authorKhawaja, HAen_US
dc.contributor.authorLek, Men_US
dc.contributor.authorMcCarthy, Sen_US
dc.contributor.authorMcEachan, Ren_US
dc.contributor.authorO'Donnell-Luria, Aen_US
dc.contributor.authorPaigen, Ken_US
dc.contributor.authorParisinos, CAen_US
dc.contributor.authorSheridan, Een_US
dc.contributor.authorSouthgate, Len_US
dc.contributor.authorTee, Len_US
dc.contributor.authorThomas, Men_US
dc.contributor.authorXue, Yen_US
dc.contributor.authorSchnall-Levin, Men_US
dc.contributor.authorPetkov, PMen_US
dc.contributor.author-Smith, CTen_US
dc.contributor.authorMaher, ERen_US
dc.contributor.authorTrembath, RCen_US
dc.contributor.authorMacArthur, DGen_US
dc.contributor.authorWright, Jen_US
dc.contributor.authorDurbin, Ren_US
dc.contributor.authorvan Heel, DAen_US
dc.date.accessioned2016-04-05T09:19:28Z
dc.date.available2016-02-18en_US
dc.date.issued2016-04-22en_US
dc.date.submitted2016-03-22T16:08:14.872Z
dc.identifier.issn0036-8075en_US
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/11646
dc.description.sponsorshipThe study was funded by the Wellcome Trust (WT102627 and WT098051), Barts Charity (845/1796), Medical Research Council (MR/M009017/1). This paper presents independent research funded by the National Institute for Health Research (NIHR) under its Collaboration for Applied Health Research and Care (CLAHRC) for Yorkshire and Humber. Core support for Born in Bradford is also provided by the Wellcome Trust (WT101597). V.N. was supported by the Wellcome Trust PhD Studentship (WT099769). D.G.M. and K.K. were supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number R01GM104371. E.R.M. is funded by NIHR Cambridge Biomedical Research Centre. H.H. is supported by awards to establish the Farr Institute of Health Informatics Research, London, from the Medical Research Council, Arthritis Research UK, British Heart Foundation, Cancer Research UK, Chief Scientist Office, Economic and Social Research Council, Engineering and Physical Sciences Research Council, NIHR, National Institute for Social Care and Health Research, and Wellcome Trust.en_US
dc.format.extent474 - 477en_US
dc.language.isoenen_US
dc.relation.ispartofSCIENCEen_US
dc.rightsThis is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on 03 Mar 2016, DOI: 10.1126/science.aac8624.
dc.titleHealth and population effects of rare gene knockouts in adult humans with related parentsen_US
dc.typeArticle
dc.rights.holderCopyright © 2016, American Association for the Advancement of Science.
dc.identifier.doi10.1126/science.aac8624en_US
pubs.author-urlhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000374479700051&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6aen_US
pubs.issue6284en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume352en_US


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