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SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair

dc.contributor.authorKanu, Nen_US
dc.contributor.authorGroenroos, Een_US
dc.contributor.authorMartinez, Pen_US
dc.contributor.authorBurrell, RAen_US
dc.contributor.authorGoh, XYen_US
dc.contributor.authorBartkova, Jen_US
dc.contributor.authorMaya-Mendoza, Aen_US
dc.contributor.authorMistrik, Men_US
dc.contributor.authorRowan, AJen_US
dc.contributor.authorPatel, Hen_US
dc.contributor.authorRabinowitz, Aen_US
dc.contributor.authorEast, Pen_US
dc.contributor.authorWilson, Gen_US
dc.contributor.authorSantos, CRen_US
dc.contributor.authorMcGranahan, Nen_US
dc.contributor.authorGulati, Sen_US
dc.contributor.authorGerlinger, Men_US
dc.contributor.authorBirkbak, NJen_US
dc.contributor.authorJoshi, Ten_US
dc.contributor.authorAlexandrov, LBen_US
dc.contributor.authorStratton, MRen_US
dc.contributor.authorPowles, Ten_US
dc.contributor.authorMatthews, Nen_US
dc.contributor.authorBates, PAen_US
dc.contributor.authorStewart, Aen_US
dc.contributor.authorSzallasi, Zen_US
dc.contributor.authorLarkin, Jen_US
dc.contributor.authorBartek, Jen_US
dc.contributor.authorSwanton, Cen_US
dc.date.accessioned2016-02-02T15:51:36Z
dc.date.available2015-01-06en_US
dc.date.issued2015-11-12en_US
dc.date.submitted2016-01-13T14:28:56.653Z
dc.identifier.issn0950-9232en_US
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/11014
dc.description.sponsorshipThe research leading to these results is supported by Cancer Research UK (XYG, RAB, EG, PM, PE, SG, C Santos, AJR, NM, PAB, AS and C Swanton), Breast Cancer Research Foundation (C Swanton and NK), Medical Research Council (ID: G0902275 to MG and C Santos; ID: G0701935/2 to AJR and C Swanton), the Danish Cancer Society (AMM, J Bartkova and J Bartek), the Lundbeck Foundation (R93-A8990 to J Bartek), the Ministry of the interior of the Czech Republic (grant VG20102014001 to MM and J Bartek), the National Program of Sustainability (grant LO1304 to MM and J Bartek), the Danish Council for Independent Research (grant DFF-1331-00262 to J Bartek), NIHR RMH/ICR Biomedical Research Centre for Cancer (JL), the EC Framework 7 (PREDICT 259303 to XYG, EG, PM, MG, TJ and C Swanton; DDResponse 259892 to J Bartek and J Bartkova and RESPONSIFY ID:259303 to C Swanton), UCL Overseas Research Scholarship (SG). C Swanton is also supported by the European Research Council, Rosetrees Trust and The Prostate Cancer Foundation. This research is supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre.en_US
dc.format.extent5699 - 5708en_US
dc.relation.ispartofONCOGENEen_US
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.
dc.titleSETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repairen_US
dc.typeArticle
dc.rights.holder© The Author(s) 2015
dc.identifier.doi10.1038/onc.2015.24en_US
pubs.author-urlhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000364594600002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6aen_US
pubs.issue46en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume34en_US


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