dc.contributor.author | Chandrasekaran, D | en_US |
dc.contributor.author | Menon, U | en_US |
dc.contributor.author | Evans, G | en_US |
dc.contributor.author | Crawford, R | en_US |
dc.contributor.author | Saridogan, E | en_US |
dc.contributor.author | Jacobs, C | en_US |
dc.contributor.author | Tischkowitz, M | en_US |
dc.contributor.author | Brockbank, E | en_US |
dc.contributor.author | Kalsi, J | en_US |
dc.contributor.author | Jurkovic, D | en_US |
dc.contributor.author | Manchanda, R | en_US |
dc.date.accessioned | 2016-01-19T16:44:53Z | |
dc.date.available | 2015-07-10 | en_US |
dc.date.issued | 2015-07-16 | en_US |
dc.identifier.issn | 1573-7292 | en_US |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/10800 | |
dc.description.abstract | Risk-reducing-salpingectomy and Delayed-Oophorectomy (RRSDO) is being proposed as a two-staged approach in place of RRSO to reduce the risks associated with premature menopause in high-risk women. We report on the acceptability/attitude of UK health professionals towards RRSDO. An anonymised web-based survey was sent to UK Cancer Genetics Group (CGG) and British Gynaecological Cancer Society (BGCS) members to assess attitudes towards RRSDO. Baseline characteristics were described using descriptive statistics. A Chi square test was used to compare categorical, Kendal-tau-b test for ordinal and Mann–Whitney test for continuous variables between two groups. 173/708 (24.4 %) of invitees responded. 71 % respondents (CGG = 57 %/BGCS = 83 %, p = 0.005) agreed with the tubal hypothesis for OC, 55 % (CGG = 42 %/BGCS = 66 %, p = 0.003) had heard of RRSDO and 48 % (CGG = 46 %/BGCS = 50 %) felt evidence was not currently strong enough for introduction into clinical practice. However, 60 % respondents’ (CGG = 48 %/BGCS = 71 %, p = 0.009) favoured offering RRSDO to high-risk women declining RRSO, 77 % only supported RRSDO within a clinical trial (CGG = 78 %/BGCS = 76 %) and 81 % (CGG = 76 %/BGCS = 86 %) advocated a UK-wide registry. Vasomotor symptoms (72 %), impact on sexual function (63 %), osteoporosis (59 %), hormonal-therapy (55 %) and subfertility (48 %) related to premature menopause influenced their choice of RRSDO. Potential barriers to offering the two-stage procedure included lack of data on precise level of benefit (83 %), increased surgical morbidity (79 %), loss of breast cancer risk reduction associated with oophorectomy (68 %), need for long-term follow-up (61 %) and a proportion not undergoing DO (66 %). There were variations in perception between BGCS/CGG members which are probably attributable to differences in clinical focus/expertise between these two groups. Despite concerns, there is reasonable support amongst UK clinicians to offering RRSDO to premenopausal high-risk women wishing to avoid RRSO, within a prospective clinical trial. | en_US |
dc.description.sponsorship | This work has not been directly funded by any commercial organisation, or charity. | en_US |
dc.format.extent | 521 - 530 (10) | en_US |
dc.language | English | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer Verlag (Germany) | en_US |
dc.relation.ispartof | Familial Cancer | en_US |
dc.rights | The final publication is available at Springer via http://dx.doi.org/10.1007/s10689-015-9823-y | |
dc.subject | Risk reducing salpingectomy | en_US |
dc.subject | Delayed oophorectomy | en_US |
dc.subject | RRSDO | en_US |
dc.subject | BRCA | en_US |
dc.subject | High-risk | en_US |
dc.subject | Ovarian cancer | en_US |
dc.title | Risk Reducing Salpingectomy and Delayed Oophorectomy in high risk women: views of cancer geneticists, genetic counsellors and gynaecological oncologists in the UK | en_US |
dc.type | Article | |
dc.rights.holder | © Springer Science+Business Media Dordrecht 2015 | |
dc.identifier.doi | 10.1007/s10689-015-9823-y | en_US |
pubs.issue | 4 | en_US |
pubs.notes | 12 months | en_US |
pubs.publication-status | Published | en_US |
pubs.publisher-url | http://link.springer.com/article/10.1007/s10689-015-9823-y | en_US |
pubs.volume | 14 | en_US |
dcterms.dateAccepted | 2015-07-10 | en_US |