CTCF binds to sites in the major histocompatibility complex that are rapidly reconfigured in response to interferon-gamma.
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Activation of the major histocompatibility complex (MHC) by interferon-gamma (IFN-γ) is a fundamental step in the adaptive immune response to pathogens. Here, we show that reorganization of chromatin loop domains in the MHC is evident within the first 30 min of IFN-γ treatment of fibroblasts, and that further dynamic alterations occur up to 6 h. These very rapid changes occur at genomic sites which are occupied by CTCF and are close to IFN-γ-inducible MHC genes. Early responses to IFN-γ are thus initiated independently of CIITA, the master regulator of MHC class II genes and prepare the MHC for subsequent induction of transcription.
AuthorsOttaviani, D; Lever, E; Mao, S; Christova, R; Ogunkolade, BW; Jones, TA; Szary, J; Aarum, J; Mumin, MA; Pieri, CA; Krawetz, SA; Sheer, D
- Genomic Medicine