Browsing by Title
Now showing items 19710-19729 of 40622
-
Investigating the role of TCR signalling during T cell development
(Queen Mary University of London, 23/11/2015)The thymus generates multiple T cell populations from an early common CD4(-) CD8(-) double negative (DN) progenitor. Conventional αβ T cells, such as CD4(+) and CD8(+) T cells undergo thymic positive selection on partial ... -
Investigating the role of the Notch atypical ligand, delta-like homologue 1 (DLK1) in adrenocortical carcinoma
(Queen Mary University of London, 2023)Adrenocortical carcinoma (ACC) is a rare malignancy with limited treatment options and a heterogenous prognosis. The histological diagnosis of ACC is complex and there is increasing interest in identifying and validating ... -
Investigating the role of tumour-associated macrophages in a mouse model of B-cell Non- Hodgkin Lymphoma
(Queen Mary University of London, 2012)A large number of infiltrating tumour-associated macrophages (TAM) is associated with a poor prognosis in many diverse cancers. In B-cell Non- Hodgkin Lymphomas (B-NHL), the situation is less clear with conflicting ... -
Investigating the Role of VEGF-D in the Pathophysiology and Treatment of Coronary Ischaemia
This thesis investigates the role of Vascular Endothelial Growth Factor-D as a biomarker for clinical conditions and symptoms and its therapeutic potential in coronary ischaemia. The initial chapters provide a detailed ... -
Investigating the role of versican in immune exclusion in triple negative breast cancer
Triple negative breast cancer has the highest T cell infiltrate in comparison to other subtypes of breast cancer. To try to improve the anti-tumour response of these T cells, immunotherapy has been trialled, however clinical ... -
Investigating the roles of HMGB1 and its receptor, RAGE, in chronic lymphocytic leukaemia
(Queen Mary University of London, 02/10/2018)High plasma levels of inflammatory mediator, high mobility group box protein 1 (HMGB1), and its main receptor, receptor for advanced glycation end products (RAGE), is associated with poor prognosis for a variety of cancers, ... -
Investigating the roles of the alternative Isoforms of the preTCR alpha (pTα) chain in T cell development
(2010)The pre-T cell receptor (preTCR) is required for αβ T cell development and hence efficient adaptive immunity. Composed of a rearranged TCRβ chain paired with the invariant preTCR α chain (pTα), it drives immature thymocytes ... -
Investigating the stratified efficacy and safety of pharmacological blood pressure-lowering: an overall protocol for individual patient-level data meta-analyses of over 300 000 randomised participants in the new phase of the Blood Pressure Lowering Treatment Trialists’ Collaboration (BPLTTC)
(BMJ Journals, 2019-05)INTRODUCTION: Previous research from the Blood Pressure Lowering Treatment Trialists' Collaboration (BPLTTC) and others has shown that pharmacological blood pressure (BP)- lowering substantially reduces the risk of major ... -
Investigating the Stress and Strain fields in Porous Synthetic Bone Graft Substitute Materials with Varied Porosity Levels
(Queen Mary University of London, 27/11/2019)Porous hydroxyapatite (PHA) ceramic granules have been found to be highly successful synthetic bone graft substitute (BGS) materials, encouraging rapid, good quality bone healing. Key to the success of these materials is ... -
Investigating the transformative potential of different TP53 mutations in cell line models of early high-grade serous ovarian cancer
(Queen Mary University of London, 2016-03-31)High-grade serous ovarian cancer (HGSC) is the most common and aggressive form of ovarian cancer, accounting over 60% of cases and up to 90% of ovarian cancer related deaths. Mutant TP53 appears to be a consistent and ... -
Investigating the viability of sulfur polymers for the fabrication of photoactive, antimicrobial, water repellent coatings
(Royal Society of Chemistry, 2022-04-11)Elemental sulfur (S8), a by-product of the petroleum refining industries, possesses many favourable properties including photocatalytic activity and antibacterial activity, in addition to being intrinsically hydrophobic. ... -
Investigating the Wnt/β-catenin Pathway in Conventional Dendritic cells in Obesity-Induced Tissue Inflammation and Insulin Resistance
(Queen Mary University of London, 07/03/2019)Chronic low-grade inflammation in visceral adipose tissue (VAT) is a key feature of obesity and crucial in the development of insulin resistance (IR) and type 2 diabetes mellitus (T2DM). VAT harbours resident immune cells ... -
Investigating therapeutic senescence using the melanocortin 1 receptor agonist BMS-470539 in the treatment of fibroblast-driven disease
Fibroblasts have well described roles in production of the extracellular matrix and are key players in wound healing. However, it has become clear that these cells are important disease-drivers in a number of pathologies, ... -
Investigating Topic Modelling for Therapy Dialogue Analysis
(Association for Computational Linguistics, 2013-03) -
INVESTIGATING TWO-STAGE MACHINE LEARNING TECHNIQUES FOR HEART ARRHYTHMIA CLASSIFICATION
Heart arrhythmia classification plays a crucial role in diagnosing and treating cardiac conditions. This study focuses on investigating the efficacy of a two-stage approach for automatic heart arrhythmia classification ... -
Investigating Wound Healing Characteristics of Gingival and Skin Keratinocytes
(Queen Mary University of London, 17/12/2018)Oral tissue, including gingiva, is recognised for its ability to heal both at an accelerated rate and with reduced scarring. The aim of this project was to explore the contrasting healing efficiencies of gingival versus ...
