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Now showing items 3063-3082 of 43281
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B cell depletion with rituximab in the treatment of primary Sjögren's syndrome: what have we learnt?
(2019-05)Despite the well-established role of B cells in the pathogenesis of primary Sjögren's syndrome (pSS), the beneficial role of B-cell depletion therapy with rituximab remains elusive in this condition, contrary to other ... -
B Cell Mobilization, Dissemination, Fine Tuning of Local Antigen Specificity and Isotype Selection in Asthma.
(Frontiers Media, 2021-10-14)In order to better understand how the immune system interacts with environmental triggers to produce organ-specific disease, we here address the hypothesis that B and plasma cells are free to migrate through the mucosal ... -
B Cell Synovitis and Clinical Phenotypes in Rheumatoid Arthritis: Relationship to Disease Stages and Drug Exposure.
(2019-11-29)OBJECTIVE: To define the relationship of synovial B cells to clinical phenotypes at different stages of disease evolution and drug exposure in rheumatoid arthritis (RA). METHODS: Synovial biopsy specimens and demographic ... -
B CELL-RICH SYNOVITIS IN EARLY AND ESTABLISHED RHEUMATOID ARTHRITIS
(2020-04)Meeting abstract P233 from British Society for Rheumatology Annual Conference 2020 -
B Cells and EBV Infection in People with MS
(2009-03-17) -
B cells defined by immunoglobulin isotypes
(Oxford University Press, 2022-10-05) -
B cells in pancreatic cancer stroma
(2022) -
B cells in the formation of Tertiary Lymphoid Organs in autoimmunity, transplantation and tumorigenesis.
(Elsevier, 2019-02-22)TLS develop in target organs of autoimmune diseases, transplantation and cancer. • TLS can function as germinal centres supporting B-cell selection/differentiation. • TLS can be destructive or have beneficial effects ... -
B-cell depletion in Rheumatoid Arthritis: clinical, biochemical and synovial predictors of response
(2019-09-04)Despite a growing armamentarium of therapies available to treat rheumatoid arthritis (RA), predicting response to therapy remains a clinical challenge. Witnessed variability in treatment outcomes translates to a large unmet ... -
B-cell receptor signaling in chronic lymphocytic leukemia.
(2011-10-20)The B-cell receptor (BCR) is a key survival molecule for normal B cells and for most B-cell malignancies. Recombinatorial and mutational patterns in the clonal immunoglobulin (Ig) of chronic lymphocytic leukemia (CLL) have ... -
B-Cell Receptor Signalling in Chronic Lymphocytic Leukaemia.
(Queen Mary University of London, 2013)Chronic Lymphocytic Leukaemia (CLL) cells may depend on B-cell receptor (BCR) signalling as well as other microenvironmental survival signals. A peculiarity of CLL is that cells preserve IgD signalling in the presence of ... -
B-cell-specific checkpoint molecules that regulate anti-tumour immunity.
(2023-07)The role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour growth1,2. Here, using high-throughput flow cytometry ...
