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Now showing items 17615-17634 of 40629
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Immunogenicity of biologics used in the treatment of inflammatory bowel disease: A review.
(2021-06-19)PURPOSE OF THE REVIEW: Here we critically evaluate the literature on immunotherapy failure in inflammatory bowel disease patients. In particular anti-drug antibody production, and subsequently loss of response as the primary ... -
Immunogenicity of biologics used in the treatment of moderate to severe psoriasis
(IOS Press, 2021-06-11)The number of biologic drugs available for the treatment of psoriasis continue to expand. However, being biological proteins and thus potentially immunogenic, there is evidence that anti-drug-antibodies develop against the ... -
Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts.
(2021-10)BACKGROUND & AIMS: Colorectal cancer (CRC) shows variable response to immune checkpoint blockade, which can only partially be explained by high tumor mutational burden (TMB). We conducted an integrated study of the cancer ... -
Immunological monitoring of the B-cell compartment in renal transplant recipients.
(Queen Mary University of London, 2014-09)B cells contribute to chronic allograft deterioration, negatively impacting graft survival, and curtailing the lifespan of a resource already in short supply. Given this, identifying alloreactive B cells could generate ... -
An immunologist's guide to CD31 function in T-cells
(2013-06-01) -
Immunology in the Era of Single-Cell Technologies
(Annual Reviews, 2020-02-19) -
Immunometabolic cross-talk in the inflamed heart.
(2019-06-07)Inflammatory processes underlie many diseases associated with injury of the heart muscle, including conditions without an obvious inflammatory pathogenic component such as hypertensive and diabetic cardiomyopathy. Persistence ... -
Immunometabolic Mechanisms of Heart Failure with Preserved Ejection Fraction.
(2022-03)Heart failure with preserved ejection fraction (HFpEF) is increasing in prevalence worldwide, already accounting for at least half of all heart failure (HF). As most patients with HFpEF are obese with metabolic syndrome, ... -
Immunomodulatory actions of vitamin D in the protection against acute respiratory infections
(Queen Mary University of London, 2014-10-28)Introduction: Vitamin D is a micronutrient that possesses immunomodulatory actions. Higher vitamin D status has been associated with decreased incidence of acute respiratory infections (ARI) in a number of observational ... -
The Immunomodulatory Effects of Surgery on T Cell Metabolism
The immune response to surgery is characterised by broad postoperative immunosuppression of the adaptive arm and has been associated with increased postoperative morbidity. Metabolism has been implicated in these mechanisms, ... -
Immunomodulatory effects of Zingiber officinale Roscoe var. rubrum (Halia Bara) on inflammatory responses relevant to psoriasis
(Queen Mary University of London, 2012)Psoriasis is a chronic autoimmune skin disease characterised by hyperplasia of epidermal keratinocytes and the accumulation of activated immune cells at sites of the disease. The disease is associated with aberrant activation ...
