dc.contributor.author | Scopazzini, MS | en_US |
dc.contributor.author | Chansa, P | en_US |
dc.contributor.author | Majonga, ED | en_US |
dc.contributor.author | Bual, N | en_US |
dc.contributor.author | Schaap, A | en_US |
dc.contributor.author | Mateyo, KJ | en_US |
dc.contributor.author | Musukuma, R | en_US |
dc.contributor.author | Mweemba, V | en_US |
dc.contributor.author | Cheeba, M | en_US |
dc.contributor.author | Mwila, CC | en_US |
dc.contributor.author | Sigande, L | en_US |
dc.contributor.author | Banda, I | en_US |
dc.contributor.author | Ngulube, J | en_US |
dc.contributor.author | Shanaube, K | en_US |
dc.contributor.author | Zenner, D | en_US |
dc.contributor.author | Ayles, H | en_US |
dc.contributor.author | Shah, ASV | en_US |
dc.date.accessioned | 2024-07-29T10:17:53Z | |
dc.date.available | 2024-04-03 | en_US |
dc.date.issued | 2024-04-10 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/98447 | |
dc.description.abstract | BACKGROUND: Tuberculosis (TB) continues to be a major cause of death across sub-Saharan Africa (SSA). In parallel, non-communicable disease and especially cardiovascular disease (CVD) burden has increased substantially in the region. Cardiac manifestations of TB are well-recognised but the extent to which they co-exist with pulmonary TB (PTB) has not been systematically evaluated. The aim of this study is to improve understanding of the burden of cardiac pathology in PTB in those living with and without HIV in a high-burden setting. METHODS: This is a cross-sectional and natural history study to evaluate the burden and natural history of cardiac pathology in participants with PTB in Lusaka, Zambia, a high burden setting for TB and HIV. Participants with PTB, with and without HIV will be consecutively recruited alongside age- and sex-matched TB-uninfected comparators on a 2:1 basis. Participants will undergo baseline assessments to collect clinical, socio-demographic, functional, laboratory and TB disease impact data followed by point-of-care and standard echocardiography. Participants with PTB will undergo further repeat clinical and functional examination at two- and six months follow-up. Those with cardiac pathology at baseline will undergo repeat echocardiography at six months. DISCUSSION: The outcomes of the study are to a) determine the burden of cardiac pathology at TB diagnosis, b) describe its association with patient-defining risk factors and biochemical markers of cardiac injury and stretch and c) describe the natural history of cardiac pathology during the course of TB treatment. | en_US |
dc.format.extent | 205 - ? | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | BMC Cardiovasc Disord | en_US |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | |
dc.subject | Cardiac biomarkers | en_US |
dc.subject | Cardiovascular disease | en_US |
dc.subject | Echocardiography | en_US |
dc.subject | Non-communicable diseases | en_US |
dc.subject | Pulmonary tuberculosis | en_US |
dc.subject | Humans | en_US |
dc.subject | Zambia | en_US |
dc.subject | HIV Infections | en_US |
dc.subject | Prevalence | en_US |
dc.subject | Cross-Sectional Studies | en_US |
dc.subject | Tuberculosis | en_US |
dc.title | The burden and natural history of cardiac pathology at TB diagnosis in a high-HIV prevalence district in Zambia: protocol for the TB-Heart study. | en_US |
dc.type | Article | |
dc.rights.holder | © The Author(s) 2024. | |
dc.identifier.doi | 10.1186/s12872-024-03877-0 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/38600454 | en_US |
pubs.issue | 1 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 24 | en_US |
dcterms.dateAccepted | 2024-04-03 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |
rioxxterms.funder.project | b215eee3-195d-4c4f-a85d-169a4331c138 | en_US |