dc.contributor.author | Dashtban, A | en_US |
dc.contributor.author | Mizani, M | en_US |
dc.contributor.author | Pasea, L | en_US |
dc.contributor.author | Tomlinson, C | en_US |
dc.contributor.author | Mu, Y | en_US |
dc.contributor.author | Islam, N | en_US |
dc.contributor.author | Rafferty, S | en_US |
dc.contributor.author | Warren-Gash, PC | en_US |
dc.contributor.author | Denaxas, PS | en_US |
dc.contributor.author | Horstmanshof, K | en_US |
dc.contributor.author | Kontopantelis, PE | en_US |
dc.contributor.author | Petersen, PS | en_US |
dc.contributor.author | Sudlow, PC | en_US |
dc.contributor.author | Khunti, PK | en_US |
dc.contributor.author | Banerjee, PA | en_US |
dc.contributor.author | CVD-COVID-UK/COVID-IMPACT Consortium | en_US |
dc.date.accessioned | 2024-07-09T07:29:27Z | |
dc.date.available | 2024-06-23 | en_US |
dc.date.issued | 2024-06-26 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/97918 | |
dc.description.abstract | OBJECTIVE: To identify highest-risk subgroups for COVID-19 and Long COVID(LC), particularly in contexts of influenza and cardiovascular disease(CVD). METHODS: Using national, linked electronic health records for England(NHS England Secure Data Environment via CVD-COVID-UK/COVID-IMPACT Consortium), we studied individuals(of all ages) with COVID-19 and LC (2020-2023). We compared all-cause hospitalisation and mortality by prior CVD, high CV risk, vaccination status(COVID-19/influenza), and CVD drugs, investigating impact of vaccination and CVD prevention using population preventable fractions. RESULTS: Hospitalisation and mortality were 15.3% and 2.0% among 17,373,850 individuals with COVID-19(LC rate 1.3%), and 16.8% and 1.4% among 301,115 with LC. Adjusted risk of mortality and hospitalisation were reduced with COVID-19 vaccination≥2 doses(COVID-19:HR 0.36 and 0.69; LC:0.44 and 0.90). With influenza vaccination, mortality was reduced, but not hospitalisation(COVID-19:0.86 and 1.01, and LC:0.72 and 1.05). Mortality and hospitalisation were reduced by CVD prevention in those with CVD, e.g. anticoagulants- COVID:19:0.69 and 0.92; LC:0.59 and 0.88; lipid lowering- COVID-19:0.69 and 0.86; LC:0.68 and 0.90. COVID-19 vaccination averted 245044 of 321383 and 7586 of 8738 preventable deaths after COVID-19 and LC, respectively. INTERPRETATION: Prior CVD and high CV risk are associated with increased hospitalisation and mortality in COVID-19 and LC. Targeted COVID-19 vaccination and CVD prevention are priority interventions. FUNDING: NIHR. HDR UK. | en_US |
dc.format.extent | 107155 - ? | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Int J Infect Dis | en_US |
dc.rights | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) | |
dc.subject | COVID-19 | en_US |
dc.subject | Long COVID | en_US |
dc.subject | cardiovascular disease | en_US |
dc.subject | vaccination | en_US |
dc.title | Vaccinations, cardiovascular drugs, hospitalisation and mortality in COVID-19 and Long COVID. | en_US |
dc.type | Article | |
dc.rights.holder | © 2024 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases | |
dc.identifier.doi | 10.1016/j.ijid.2024.107155 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/38942167 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
dcterms.dateAccepted | 2024-06-23 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |