dc.contributor.author | Fiddaman, SR | en_US |
dc.contributor.author | Dimopoulos, EA | en_US |
dc.contributor.author | Lebrasseur, O | en_US |
dc.contributor.author | du Plessis, L | en_US |
dc.contributor.author | Vrancken, B | en_US |
dc.contributor.author | Charlton, S | en_US |
dc.contributor.author | Haruda, AF | en_US |
dc.contributor.author | Tabbada, K | en_US |
dc.contributor.author | Flammer, PG | en_US |
dc.contributor.author | Dascalu, S | en_US |
dc.contributor.author | Marković, N | en_US |
dc.contributor.author | Li, H | en_US |
dc.contributor.author | Franklin, G | en_US |
dc.contributor.author | Symmons, R | en_US |
dc.contributor.author | Baron, H | en_US |
dc.contributor.author | Daróczi-Szabó, L | en_US |
dc.contributor.author | Shaymuratova, DN | en_US |
dc.contributor.author | Askeyev, IV | en_US |
dc.contributor.author | Putelat, O | en_US |
dc.contributor.author | Sana, M | en_US |
dc.contributor.author | Davoudi, H | en_US |
dc.contributor.author | Fathi, H | en_US |
dc.contributor.author | Mucheshi, AS | en_US |
dc.contributor.author | Vahdati, AA | en_US |
dc.contributor.author | Zhang, L | en_US |
dc.contributor.author | Foster, A | en_US |
dc.contributor.author | Sykes, N | en_US |
dc.contributor.author | Baumberg, GC | en_US |
dc.contributor.author | Bulatović, J | en_US |
dc.contributor.author | Askeyev, AO | en_US |
dc.contributor.author | Askeyev, OV | en_US |
dc.contributor.author | Mashkour, M | en_US |
dc.contributor.author | Pybus, OG | en_US |
dc.contributor.author | Nair, V | en_US |
dc.contributor.author | Larson, G | en_US |
dc.contributor.author | Smith, AL | en_US |
dc.contributor.author | Frantz, LAF | en_US |
dc.date.accessioned | 2024-06-18T10:27:29Z | |
dc.date.issued | 2023-12-15 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/97505 | |
dc.description.abstract | The pronounced growth in livestock populations since the 1950s has altered the epidemiological and evolutionary trajectory of their associated pathogens. For example, Marek's disease virus (MDV), which causes lymphoid tumors in chickens, has experienced a marked increase in virulence over the past century. Today, MDV infections kill >90% of unvaccinated birds, and controlling it costs more than US$1 billion annually. By sequencing MDV genomes derived from archeological chickens, we demonstrate that it has been circulating for at least 1000 years. We functionally tested the Meq oncogene, one of 49 viral genes positively selected in modern strains, demonstrating that ancient MDV was likely incapable of driving tumor formation. Our results demonstrate the power of ancient DNA approaches to trace the molecular basis of virulence in economically relevant pathogens. | en_US |
dc.format.extent | 1276 - 1281 | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Science | en_US |
dc.rights | This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science Vol 382, Issue 6676 on 14 December 2023, DOI: 10.1126/science.adg2238 | |
dc.subject | Animals | en_US |
dc.subject | Chickens | en_US |
dc.subject | Herpesvirus 2, Gallid | en_US |
dc.subject | Lymphoma | en_US |
dc.subject | Marek Disease | en_US |
dc.subject | Virulence | en_US |
dc.subject | Phylogeny | en_US |
dc.title | Ancient chicken remains reveal the origins of virulence in Marek's disease virus. | en_US |
dc.type | Article | |
dc.identifier.doi | 10.1126/science.adg2238 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/38096384 | en_US |
pubs.issue | 6676 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 382 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |