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dc.contributor.authorEstarellas, M
dc.contributor.authorHuntley, J
dc.contributor.authorBor, D
dc.date.accessioned2024-06-07T08:45:07Z
dc.date.available2024-05-23
dc.date.available2024-06-07T08:45:07Z
dc.date.issued2024-06-04
dc.identifier.citationEstarellas M, Huntley J, Bor D. Neural markers of reduced arousal and consciousness in mild cognitive impairment. Int J Geriatr Psychiatry. 2024;e6112. https://doi.org/10.1002/gps.6112en_US
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/97332
dc.description.abstractOBJECTIVES: People with Alzheimer's Disease (AD) experience changes in their level and content of consciousness, but there is little research on biomarkers of consciousness in pre-clinical AD and Mild Cognitive Impairment (MCI). This study investigated whether levels of consciousness are decreased in people with MCI. METHODS: A multi-site site magnetoencephalography (MEG) dataset, BIOFIND, comprising 83 people with MCI and 83 age matched controls, was analysed. Arousal (and drowsiness) was assessed by computing the theta-alpha ratio (TAR). The Lempel-Ziv algorithm (LZ) was used to quantify the information content of brain activity, with higher LZ values indicating greater complexity and potentially a higher level of consciousness. RESULTS: LZ was lower in the MCI group versus controls, indicating a reduced level of consciousness in MCI. TAR was higher in the MCI group versus controls, indicating a reduced level of arousal (i.e. increased drowsiness) in MCI. LZ was also found to be correlated with mini-mental state examination (MMSE) scores, suggesting an association between cognitive impairment and level of consciousness in people with MCI. CONCLUSIONS: A decline in consciousness and arousal can be seen in MCI. As cognitive impairment worsens, measured by MMSE scores, levels of consciousness and arousal decrease. These findings highlight how monitoring consciousness using biomarkers could help understand and manage impairments found at the preclinical stages of AD. Further research is needed to explore markers of consciousness between people who progress from MCI to dementia and those who do not, and in people with moderate and severe AD, to promote person-centred care.en_US
dc.format.extente6112 - ?
dc.languageeng
dc.publisherWileyen_US
dc.relation.ispartofInt J Geriatr Psychiatry
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.subjectAlzheimer's diseaseen_US
dc.subjectageingen_US
dc.subjectcomplexityen_US
dc.subjectconsciousnessen_US
dc.subjectdementiaen_US
dc.subjectlempel ziven_US
dc.subjectHumansen_US
dc.subjectCognitive Dysfunctionen_US
dc.subjectFemaleen_US
dc.subjectMaleen_US
dc.subjectAgeden_US
dc.subjectArousalen_US
dc.subjectAged, 80 and overen_US
dc.subjectCase-Control Studiesen_US
dc.subjectMagnetoencephalographyen_US
dc.subjectConsciousnessen_US
dc.subjectAlzheimer Diseaseen_US
dc.subjectBiomarkersen_US
dc.subjectAlgorithmsen_US
dc.subjectMiddle Ageden_US
dc.subjectMental Status and Dementia Testsen_US
dc.titleNeural markers of reduced arousal and consciousness in mild cognitive impairment.en_US
dc.typeArticleen_US
dc.rights.holder© 2024 The Author(s). International Journal of Geriatric Psychiatry published by John Wiley & Sons Ltd.
dc.identifier.doi10.1002/gps.6112
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/38837281en_US
pubs.issue6en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume39en_US
dcterms.dateAccepted2024-05-23
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
qmul.funderThe neural markers of cognitive reserve::Wellcome Trusten_US


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