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dc.contributor.authorShephard, E
dc.contributor.authorMilosavljevic, B
dc.contributor.authorMason, L
dc.contributor.authorElsabbagh, M
dc.contributor.authorTye, C
dc.contributor.authorGliga, T
dc.contributor.authorJones, EJH
dc.contributor.authorCharman, T
dc.contributor.authorJohnson, MH
dc.date.accessioned2024-05-01T10:09:28Z
dc.date.available2020-02-19
dc.date.available2024-05-01T10:09:28Z
dc.date.issued2020-02-29
dc.identifier.citationElizabeth Shephard, Bosiljka Milosavljevic, Luke Mason, Mayada Elsabbagh, Charlotte Tye, Teodora Gliga, Emily JH. Jones, Tony Charman, Mark H. Johnson, Simon Baron-Cohen, Rachael Bedford, Patrick Bolton, Susie Chandler, Janice Fernandes, Holly Garwood, Kristelle Hudry, Greg Pasco, Andrew Pickles, Leslie Tucker, Agnes Volein, Neural and behavioural indices of face processing in siblings of children with autism spectrum disorder (ASD): A longitudinal study from infancy to mid-childhood, Cortex, Volume 127, 2020, Pages 162-179, ISSN 0010-9452, https://doi.org/10.1016/j.cortex.2020.02.008. (https://www.sciencedirect.com/science/article/pii/S0010945220300691) Abstract: Impaired face processing is proposed to play a key role in the early development of autism spectrum disorder (ASD) and to be an endophenotypic trait which indexes genetic risk for the disorder. However, no published work has examined the development of face processing abilities from infancy into the school-age years and how they relate to ASD symptoms in individuals with or at high-risk for ASD. In this novel study we investigated neural and behavioural measures of face processing at age 7 months and again in mid-childhood (age 7 years) as well as social-communication and sensory symptoms in siblings at high (n = 42) and low (n = 35) familial risk for ASD. In mid-childhood, high-risk siblings showed atypical P1 and N170 event-related potential correlates of face processing and, for high-risk boys only, poorer face and object recognition ability compared to low-risk siblings. These neural and behavioural atypicalities were associated with each other and with higher social-communication and sensory symptoms in mid-childhood. Additionally, more atypical neural correlates of object (but not face) processing in infancy were associated with less right-lateralised (more atypical) N170 amplitudes and greater social-communication problems in mid-childhood. The implications for models of face processing in ASD are discussed. Keywords: Autism spectrum disorder (ASD); Infant siblings; Face processing; EEG; Developmenten_US
dc.identifier.issn0010-9452
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/96579
dc.description.abstractImpaired face processing is proposed to play a key role in the early development of autism spectrum disorder (ASD) and to be an endophenotypic trait which indexes genetic risk for the disorder. However, no published work has examined the development of face processing abilities from infancy into the school-age years and how they relate to ASD symptoms in individuals with or at high-risk for ASD. In this novel study we investigated neural and behavioural measures of face processing at age 7 months and again in mid-childhood (age 7 years) as well as social-communication and sensory symptoms in siblings at high (n = 42) and low (n = 35) familial risk for ASD. In mid-childhood, high-risk siblings showed atypical P1 and N170 event-related potential correlates of face processing and, for high-risk boys only, poorer face and object recognition ability compared to low-risk siblings. These neural and behavioural atypicalities were associated with each other and with higher social-communication and sensory symptoms in mid-childhood. Additionally, more atypical neural correlates of object (but not face) processing in infancy were associated with less right-lateralised (more atypical) N170 amplitudes and greater social-communication problems in mid-childhood. The implications for models of face processing in ASD are discussed.en_US
dc.format.extent162 - 179
dc.publisherElsevieren_US
dc.relation.ispartofCORTEX
dc.rightsThis is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/).
dc.subjectAutism spectrum disorder (ASD)en_US
dc.subjectInfant siblingsen_US
dc.subjectFace processingen_US
dc.subjectEEGen_US
dc.subjectDevelopmenten_US
dc.titleNeural and behavioural indices of face processing in siblings of children with autism spectrum disorder (ASD): A longitudinal study from infancy to mid-childhooden_US
dc.typeArticleen_US
dc.rights.holder© 2020 The Authors. Published by Elsevier Ltd.
dc.identifier.doi10.1016/j.cortex.2020.02.008
pubs.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000534377300013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6aen_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume127en_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
rioxxterms.funder.project2acae7f5-fd8c-4d20-af2e-447fb9664166en_US


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