dc.contributor.author | Massey, RJJ | |
dc.contributor.author | Siddiqui, MKK | |
dc.contributor.author | Pearson, ERR | |
dc.contributor.author | Dawed, AYY | |
dc.date.accessioned | 2024-04-08T07:32:31Z | |
dc.date.available | 2022-12-31 | |
dc.date.available | 2024-04-08T07:32:31Z | |
dc.date.issued | 2023-01-09 | |
dc.identifier.citation | Massey, R.J., Siddiqui, M.K., Pearson, E.R. et al. Weight variability and cardiovascular outcomes: a systematic review and meta-analysis. Cardiovasc Diabetol 22, 5 (2023). https://doi.org/10.1186/s12933-022-01735-x | en_US |
dc.identifier.other | ARTN 5 | |
dc.identifier.other | ARTN 5 | |
dc.identifier.other | ARTN 5 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/95968 | |
dc.description.abstract | The association between body weight variability and the risk of cardiovascular disease (CVD) has been investigated previously with mixed findings. However, there has been no extensive study which systematically evaluates the current evidence. Furthermore, the impact of ethnicity and type 2 diabetes on this phenomena has not yet been investigated. Therefore, the aim of this study was to comprehensively evaluate the effect of weight variability on risk of CVD (any cardiovascular (CV) event, composite CV outcome, CV death, Stroke, Myocardial Infarction) and the influence of ethnicity and type 2 diabetes status on the observed association. A systematic review and meta-analysis was performed according to the meta-analyses of observational studies in epidemiology (MOOSE) guidelines. The electronic databases PubMed, Web of Science, and the Cochrane Library were searched for studies that investigated the relationship between body weight or BMI variability and CV diseases using Medical Subject Headings (MeSH) terms and keywords. The relative risks (RRs) for the outcomes were collected from studies, pooled, and analysed using a random-effects model to estimate the overall relative risk. Of 5645 articles screened, 23 studies with a total population of 15,382,537 fulfilled the prespecified criteria and were included. Individuals in the highest strata of body weight variability were found to have significantly increased risk of any CV event (RR = 1.27; 95% Confidence Interval (CI) 1.17–1.38; P < 0.0001; I2 = 97.28%), cardiovascular death (RR = 1.29; 95% CI 1.03–1.60; P < 0.0001; I2 = 55.16%), myocardial infarction (RR = 1.32; 95% CI 1.09–1.59; P = 0.0037; I2 = 97.14%), stroke (RR = 1.21; 95% CI 1.19–1.24; P < 0.0001; I2 = 0.06%), and compound CVD outcomes (RR = 1.36; 95% CI 1.08–1.73; P = 0.01; I2 = 92.41%). Similar RRs were observed regarding BMI variability and per unit standard deviation (SD) increase in body weight variability. Comparable effects were seen in people with and without diabetes, in White Europeans and Asians. In conclusion, body weight variability is associated with increased risk of CV diseases regardless of ethnicity or diabetes status. Future research is needed to prove a causative link between weight variability and CVD risk, as appropriate interventions to maintain stable weight could positively influence CVD. | en_US |
dc.publisher | BMC | en_US |
dc.relation.ispartof | CARDIOVASCULAR DIABETOLOGY | |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | |
dc.subject | Weight variability | en_US |
dc.subject | Obesity | en_US |
dc.subject | Cardiovascular disease | en_US |
dc.subject | Type II diabetes | en_US |
dc.subject | Meta-analysis | en_US |
dc.title | Weight variability and cardiovascular outcomes: a systematic review and meta-analysis | en_US |
dc.type | Article | en_US |
dc.rights.holder | © The Author(s) 2023. | |
dc.identifier.doi | 10.1186/s12933-022-01735-x | |
pubs.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000911334400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6a | en_US |
pubs.issue | 1 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 22 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |