dc.contributor.author | Rebolj, M | en_US |
dc.contributor.author | Brentnall, A | en_US |
dc.contributor.author | Cuschieri, K | en_US |
dc.date.accessioned | 2024-04-03T10:02:02Z | |
dc.date.available | 2024-04-02 | en_US |
dc.identifier.issn | 0007-0920 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/95879 | |
dc.description.abstract | Vaccination against human papillomavirus (HPV) is changing the performance of cytology as a cervical screening test, but its effect on HPV testing is unclear. We review the effect of HPV16/18 vaccination on the epidemiology and the detection of HPV infections and high-grade cervical lesions (CIN2+) to evaluate the likely direction of changes in HPV test accuracy. The reduction in HPV16/18 infections and cross-protection against certain non-16/18 high-risk genotypes, most notably 31, 33, and/or 45, will likely increase the test’s specificity but decrease its positive predictive value (PPV) for CIN2+. Post-vaccination viral unmasking of non-16/18 genotypes due to fewer HPV16 co-infections might reduce the specificity and the PPV for CIN2+. Post-vaccination clinical unmasking exposing a higher frequency of CIN2+ related to non-16/18 high-risk genotypes is likely to increase the specificity and the PPV of HPV tests. The effect of HPV16/18 vaccination on HPV test sensitivity is difficult to predict based on these changes alone. Programmes relying on HPV detection for primary screening should monitor the frequency of false-positive and false-negative tests in vaccinated (younger) vs. unvaccinated (older) cohorts, to assess the outcomes and performance of their service. | |
dc.language.iso | en | en_US |
dc.publisher | Springer Nature [academic journals on nature.com] | en_US |
dc.relation.ispartof | British Journal of Cancer | en_US |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | |
dc.title | PREDICTABLE CHANGES IN THE ACCURACY OF HUMAN PAPILLOMAVIRUS TESTS AFTER VACCINATION: REVIEW WITH IMPLICATIONS FOR PERFORMANCE MONITORING IN CERVICAL SCREENING | en_US |
dc.type | Article | |
dc.rights.holder | © 2024 The Author(s). Published by Nature Research | |
pubs.notes | Not known | en_US |
pubs.publication-status | Accepted | en_US |
dcterms.dateAccepted | 2024-04-02 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |