Show simple item record

dc.contributor.authorMarzuki, AA
dc.contributor.authorVaghi, MM
dc.contributor.authorConway-Morris, A
dc.contributor.authorKaser, M
dc.contributor.authorSule, A
dc.contributor.authorApergis-Schoute, A
dc.contributor.authorSahakian, BJ
dc.contributor.authorRobbins, TW
dc.date.accessioned2024-03-18T12:46:34Z
dc.date.available2022-04-13
dc.date.available2024-03-18T12:46:34Z
dc.date.issued2022-05-10
dc.identifier.citationMarzuki, A.A., Vaghi, M.M., Conway-Morris, A., Kaser, M., Sule, A., Apergis-Schoute, A., Sahakian, B.J. and Robbins, T.W. (2022), Atypical action updating in a dynamic environment associated with adolescent obsessive–compulsive disorder. J Child Psychol Psychiatr, 63: 1591-1601. https://doi.org/10.1111/jcpp.13628en_US
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/95461
dc.description.abstractBACKGROUND: Computational research had determined that adults with obsessive-compulsive disorder (OCD) display heightened action updating in response to noise in the environment and neglect metacognitive information (such as confidence) when making decisions. These features are proposed to underlie patients' compulsions despite the knowledge they are irrational. Nonetheless, it is unclear whether this extends to adolescents with OCD as research in this population is lacking. Thus, this study aimed to investigate the interplay between action and confidence in adolescents with OCD. METHODS: Twenty-seven adolescents with OCD and 46 controls completed a predictive-inference task, designed to probe how subjects' actions and confidence ratings fluctuate in response to unexpected outcomes. We investigated how subjects update actions in response to prediction errors (indexing mismatches between expectations and outcomes) and used parameters from a Bayesian model to predict how confidence and action evolve over time. Confidence-action association strength was assessed using a regression model. We also investigated the effects of serotonergic medication. RESULTS: Adolescents with OCD showed significantly increased learning rates, particularly following small prediction errors. Results were driven primarily by unmedicated patients. Confidence ratings appeared equivalent between groups, although model-based analysis revealed that patients' confidence was less affected by prediction errors compared to controls. Patients and controls did not differ in the extent to which they updated actions and confidence in tandem. CONCLUSIONS: Adolescents with OCD showed enhanced action adjustments, especially in the face of small prediction errors, consistent with previous research establishing 'just-right' compulsions, enhanced error-related negativity, and greater decision uncertainty in paediatric-OCD. These tendencies were ameliorated in patients receiving serotonergic medication, emphasising the importance of early intervention in preventing disorder-related cognitive deficits. Confidence ratings were equivalent between young patients and controls, mirroring findings in adult OCD research.en_US
dc.format.extent1591 - 1601
dc.languageeng
dc.publisherWileyen_US
dc.relation.ispartofJ Child Psychol Psychiatry
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.subjectObsessive-compulsive disorderen_US
dc.subjectadolescenceen_US
dc.subjectcognitionen_US
dc.subjectAdulten_US
dc.subjectHumansen_US
dc.subjectAdolescenten_US
dc.subjectChilden_US
dc.subjectBayes Theoremen_US
dc.subjectObsessive-Compulsive Disorderen_US
dc.subjectCompulsive Behavioren_US
dc.subjectDecision Makingen_US
dc.subjectLearningen_US
dc.titleAtypical action updating in a dynamic environment associated with adolescent obsessive-compulsive disorder.en_US
dc.typeArticleen_US
dc.rights.holder© 2022 The Authors. Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health.
dc.identifier.doi10.1111/jcpp.13628
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/35537441en_US
pubs.issue12en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume63en_US
dcterms.dateAccepted2022-04-13
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record