dc.contributor.author | Kotadia, ID | |
dc.contributor.author | Dias, M | |
dc.contributor.author | Roney, C | |
dc.contributor.author | Parker, RA | |
dc.contributor.author | O'Dowling, R | |
dc.contributor.author | Bodagh, N | |
dc.contributor.author | Lemus-Solis, J-A | |
dc.contributor.author | O'Hare, D | |
dc.contributor.author | Sim, I | |
dc.contributor.author | Newby, D | |
dc.contributor.author | Niederer, S | |
dc.contributor.author | Birns, J | |
dc.contributor.author | Sommerville, P | |
dc.contributor.author | Bhalla, A | |
dc.contributor.author | O'Neill, M | |
dc.contributor.author | Williams, SE | |
dc.date.accessioned | 2024-02-02T09:34:12Z | |
dc.date.available | 2024-02-02T09:34:12Z | |
dc.date.issued | 2023-11 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/94399 | |
dc.description.abstract | BACKGROUND: There are conflicting data on whether new-onset atrial fibrillation (AF) is independently associated with poor outcomes in COVID-19 patients. This study represents the largest dataset curated by manual chart review comparing clinical outcomes between patients with sinus rhythm, pre-existing AF, and new-onset AF. OBJECTIVE: The primary aim of this study was to assess patient outcomes in COVID-19 patients with sinus rhythm, pre-existing AF, and new-onset AF. The secondary aim was to evaluate predictors of new-onset AF in patients with COVID-19 infection. METHODS: This was a single-center retrospective study of patients with a confirmed diagnosis of COVID-19 admitted between March and September 2020. Patient demographic data, medical history, and clinical outcome data were manually collected. Adjusted comparisons were performed following propensity score matching between those with pre-existing or new-onset AF and those without AF. RESULTS: The study population comprised of 1241 patients. A total of 94 (7.6%) patients had pre-existing AF and 42 (3.4%) patients developed new-onset AF. New-onset AF was associated with increased in-hospital mortality before (odds ratio [OR] 3.58, 95% confidence interval [CI] 1.78-7.06, P < .005) and after (OR 2.80, 95% CI 1.01-7.77, P < .005) propensity score matching compared with the no-AF group. However, pre-existing AF was not independently associated with in-hospital mortality compared with patients with no AF (postmatching OR: 1.13, 95% CI 0.57-2.21, P = .732). CONCLUSION: New-onset AF, but not pre-existing AF, was independently associated with elevated mortality in patients hospitalised with COVID-19. This observation highlights the need for careful monitoring of COVID-19 patients with new-onset AF. Further research is needed to explain the mechanistic relationship between new-onset AF and clinical outcomes in COVID-19 patients. | en_US |
dc.format.extent | 700 - 707 | |
dc.language | eng | |
dc.publisher | Elsevier | en_US |
dc.relation.ispartof | Heart Rhythm O2 | |
dc.rights | This item is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | |
dc.subject | Atrial fibrillation | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | COVID-19 and arrhythmia | en_US |
dc.subject | COVID-19 and cardiovascular complications | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.title | AF and in-hospital mortality in COVID-19 patients. | en_US |
dc.type | Article | en_US |
dc.rights.holder | © 2023 Heart Rhythm Society. Published by Elsevier Inc. | |
dc.identifier.doi | 10.1016/j.hroo.2023.10.004 | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/38034887 | en_US |
pubs.issue | 11 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 4 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |