Constriction imposed by basement membrane regulates developmental cell migration
dc.contributor.author | Lopez, EM | |
dc.contributor.author | Kabanova, AM | |
dc.contributor.author | Winkel, A | |
dc.contributor.author | Franze, K | |
dc.contributor.author | Palacios, I | |
dc.contributor.author | Martin-Bermudo, MD | |
dc.date.accessioned | 2024-01-16T14:26:16Z | |
dc.date.available | 2023-05-24 | |
dc.date.available | 2024-01-16T14:26:16Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 1544-9173 | |
dc.identifier.other | ARTN e3002172 | |
dc.identifier.other | ARTN e3002172 | |
dc.identifier.other | ARTN e3002172 | |
dc.identifier.other | ARTN e3002172 | |
dc.identifier.other | ARTN e3002172 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/93942 | |
dc.description.abstract | The basement membrane (BM) is a specialized extracellular matrix (ECM), which underlies or encases developing tissues. Mechanical properties of encasing BMs have been shown to profoundly influence the shaping of associated tissues. Here, we use the migration of the border cells (BCs) of the Drosophila egg chamber to unravel a new role of encasing BMs in cell migration. BCs move between a group of cells, the nurse cells (NCs), that are enclosed by a monolayer of follicle cells (FCs), which is, in turn, surrounded by a BM, the follicle BM. We show that increasing or reducing the stiffness of the follicle BM, by altering laminins or type IV collagen levels, conversely affects BC migration speed and alters migration mode and dynamics. Follicle BM stiffness also controls pairwise NC and FC cortical tension. We propose that constraints imposed by the follicle BM influence NC and FC cortical tension, which, in turn, regulate BC migration. Encasing BMs emerge as key players in the regulation of collective cell migration during morphogenesis. | en_US |
dc.publisher | Public Library of Science | en_US |
dc.relation.ispartof | PLOS BIOLOGY | |
dc.rights | This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.title | Constriction imposed by basement membrane regulates developmental cell migration | en_US |
dc.type | Article | en_US |
dc.rights.holder | © 2023 Molina López et al. | |
dc.identifier.doi | 10.1371/journal.pbio.3002172 | |
pubs.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:001018352300003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6a | en_US |
pubs.issue | 6 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 21 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |
qmul.funder | A confocal microscope for multidisciplinary dynamic studies of complex biological systems::Biotechnology and Biological Sciences Research Council | en_US |
qmul.funder | A confocal microscope for multidisciplinary dynamic studies of complex biological systems::Biotechnology and Biological Sciences Research Council | en_US |
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