Browsing Centre for Cancer Genomics & Computational Biology by Subject "Tumor Microenvironment"
Now showing items 1-3 of 3
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Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts.
(2021-10)BACKGROUND & AIMS: Colorectal cancer (CRC) shows variable response to immune checkpoint blockade, which can only partially be explained by high tumor mutational burden (TMB). We conducted an integrated study of the cancer ... -
Mechanistic insights into the interactions between cancer drivers and the tumour immune microenvironment.
(2023-06-05)BACKGROUND: The crosstalk between cancer and the tumour immune microenvironment (TIME) has attracted significant interest in the latest years because of its impact on cancer evolution and response to treatment. Despite ... -
Reflected stemness as a potential driver of the tumour microenvironment
(2022-12)A fundamental requirement for cancer initiation is the activation of developmental programmes by mutant cells. Oncogenic signals often confer an undifferentiated, stem cell-like phenotype that supports the long-term ...