Browsing Centre for Cancer Genomics & Computational Biology by Author "Grehan, N"

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    • Mutational signature dynamics shaping the evolution of oesophageal adenocarcinoma. 

      Abbas, S; Pich, O; Devonshire, G; Zamani, SA; Katz-Summercorn, A; Killcoyne, S; Cheah, C; Nutzinger, B; Grehan, N; Lopez-Bigas, N (2023-07-15)
      A variety of mutational processes drive cancer development, but their dynamics across the entire disease spectrum from pre-cancerous to advanced neoplasia are poorly understood. We explore the mutagenic processes shaping ...

    • The transcriptional landscape of endogenous retroelements delineates esophageal adenocarcinoma subtypes. 

      Kazachenka, A; Loong, JH; Attig, J; Young, GR; Ganguli, P; Devonshire, G; Grehan, N; The OCCAMS Consortium; Ciccarelli, FD; Fitzgerald, RC (2023-09)
      Most cancer types exhibit aberrant transcriptional activity, including derepression of retrotransposable elements (RTEs). However, the degree, specificity and potential consequences of RTE transcriptional activation may ...