Browsing Centre for Cancer Genomics & Computational Biology by Author "Ciccarelli, FD"
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Apoptosis in mesenchymal stromal cells activates an immunosuppressive secretome predicting clinical response in Crohn's disease.
Cheung, TS; Giacomini, C; Cereda, M; Avivar-Valderas, A; Capece, D; Bertolino, GM; delaRosa, O; Hicks, R; Ciccocioppo, R; Franzoso, G (2023-12-06)In vivo apoptosis of human mesenchymal stromal cells (MSCs) plays a critical role in delivering immunomodulation. Yet, caspase activity not only mediates the dying process but also death-independent functions that may shape ... -
Approaching Cancer Evolution from Different Angles
Ciccarelli, FD; DeGregori, J (Cell Press, 2020-10-22)Dr Francesca Ciccarelli (The Francis Crick Institute, UK) and Dr James De Gregori (University of Colorado, USA) interview 3 top scientists in clinical (Dr Charles Swanton, The Francis Crick Institute, UK), molecular (Dr ... -
Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource.
Dressler, L; Bortolomeazzi, M; Keddar, MR; Misetic, H; Sartini, G; Acha-Sagredo, A; Montorsi, L; Wijewardhane, N; Repana, D; Nulsen, J (2022-01-26)BACKGROUND: Genetic alterations of somatic cells can drive non-malignant clone formation and promote cancer initiation. However, the link between these processes remains unclear and hampers our understanding of tissue ... -
Exome sequencing of hepatocellular carcinoma in lemurs identifies potential cancer drivers: A pilot study
Gunady, EF; Ware, KE; Hoskinson Plumlee, S; Devos, N; Corcoran, D; Prinz, J; Misetic, H; Ciccarelli, FD; Harrison, TM; Thorne, JL (Oxford University Press, 2022-04-29)BACKGROUND AND OBJECTIVES: Hepatocellular carcinoma occurs frequently in prosimians, but the cause of these liver cancers in this group is unknown. Characterizing the genetic changes associated with hepatocellular carcinoma ... -
Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts.
Bortolomeazzi, M; Keddar, MR; Montorsi, L; Acha-Sagredo, A; Benedetti, L; Temelkovski, D; Choi, S; Petrov, N; Todd, K; Wai, P (2021-10)BACKGROUND & AIMS: Colorectal cancer (CRC) shows variable response to immune checkpoint blockade, which can only partially be explained by high tumor mutational burden (TMB). We conducted an integrated study of the cancer ... -
Mechanistic insights into the interactions between cancer drivers and the tumour immune microenvironment.
Misetic, H; Keddar, MR; Jeannon, J-P; Ciccarelli, FD (2023-06-05)BACKGROUND: The crosstalk between cancer and the tumour immune microenvironment (TIME) has attracted significant interest in the latest years because of its impact on cancer evolution and response to treatment. Despite ... -
Pan-cancer detection of driver genes at the single-patient resolution.
Nulsen, J; Misetic, H; Yau, C; Ciccarelli, FD (2021-02-01)BACKGROUND: Identifying the complete repertoire of genes that drive cancer in individual patients is crucial for precision oncology. Most established methods identify driver genes that are recurrently altered across patient ... -
Reflected stemness as a potential driver of the tumour microenvironment
Rodrigues, FS; Ciccarelli, FD; Malanchi, I (2022-12)A fundamental requirement for cancer initiation is the activation of developmental programmes by mutant cells. Oncogenic signals often confer an undifferentiated, stem cell-like phenotype that supports the long-term ... -
A SIMPLI (Single-cell Identification from MultiPLexed Images) approach for spatially-resolved tissue phenotyping at single-cell resolution.
Bortolomeazzi, M; Montorsi, L; Temelkovski, D; Keddar, MR; Acha-Sagredo, A; Pitcher, MJ; Basso, G; Laghi, L; Rodriguez-Justo, M; Spencer, J (2022-02-09)Multiplexed imaging technologies enable the study of biological tissues at single-cell resolution while preserving spatial information. Currently, high-dimension imaging data analysis is technology-specific and requires ... -
The transcriptional landscape of endogenous retroelements delineates esophageal adenocarcinoma subtypes.
Kazachenka, A; Loong, JH; Attig, J; Young, GR; Ganguli, P; Devonshire, G; Grehan, N; The OCCAMS Consortium; Ciccarelli, FD; Fitzgerald, RC (2023-09)Most cancer types exhibit aberrant transcriptional activity, including derepression of retrotransposable elements (RTEs). However, the degree, specificity and potential consequences of RTE transcriptional activation may ...