Browsing Centre for Cancer Genomics & Computational Biology by Author "Bortolomeazzi, M"
Now showing items 1-4 of 4
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Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource.
Dressler, L; Bortolomeazzi, M; Keddar, MR; Misetic, H; Sartini, G; Acha-Sagredo, A; Montorsi, L; Wijewardhane, N; Repana, D; Nulsen, J (2022-01-26)BACKGROUND: Genetic alterations of somatic cells can drive non-malignant clone formation and promote cancer initiation. However, the link between these processes remains unclear and hampers our understanding of tissue ... -
Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts.
Bortolomeazzi, M; Keddar, MR; Montorsi, L; Acha-Sagredo, A; Benedetti, L; Temelkovski, D; Choi, S; Petrov, N; Todd, K; Wai, P (2021-10)BACKGROUND & AIMS: Colorectal cancer (CRC) shows variable response to immune checkpoint blockade, which can only partially be explained by high tumor mutational burden (TMB). We conducted an integrated study of the cancer ... -
Rarity: Discovering rare cell populations from single-cell imaging data
Märtens, K; Bortolomeazzi, M; Montorsi, L; Spencer, J; Ciccarelli, F; Yau, C (Oxford University Press, 2023-12-13)MOTIVATION: Cell type identification plays an important role in the analysis and interpretation of single-cell data and can be carried out via supervised or unsupervised clustering approaches. Supervised methods are best ... -
A SIMPLI (Single-cell Identification from MultiPLexed Images) approach for spatially-resolved tissue phenotyping at single-cell resolution.
Bortolomeazzi, M; Montorsi, L; Temelkovski, D; Keddar, MR; Acha-Sagredo, A; Pitcher, MJ; Basso, G; Laghi, L; Rodriguez-Justo, M; Spencer, J (2022-02-09)Multiplexed imaging technologies enable the study of biological tissues at single-cell resolution while preserving spatial information. Currently, high-dimension imaging data analysis is technology-specific and requires ...