Browsing Centre for Cancer Genomics & Computational Biology by Author "Abbas, S"
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Mutational signature dynamics shaping the evolution of oesophageal adenocarcinoma.
Abbas, S; Pich, O; Devonshire, G; Zamani, SA; Katz-Summercorn, A; Killcoyne, S; Cheah, C; Nutzinger, B; Grehan, N; Lopez-Bigas, N (2023-07-15)A variety of mutational processes drive cancer development, but their dynamics across the entire disease spectrum from pre-cancerous to advanced neoplasia are poorly understood. We explore the mutagenic processes shaping ... -
Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas.
Ng, AWT; Contino, G; Killcoyne, S; Devonshire, G; Hsu, R; Abbas, S; Su, J; Redmond, AM; Weaver, JMJ; Eldridge, MD (2022-04-08)Oesophageal adenocarcinoma (OAC) provides an ideal case study to characterize large-scale rearrangements. Using whole genome short-read sequencing of 383 cases, for which 214 had matched whole transcriptomes, we observed ...