Human complex exploration strategies are enriched by noradrenaline-modulated heuristics.
dc.contributor.author | Dubois, M | |
dc.contributor.author | Habicht, J | |
dc.contributor.author | Michely, J | |
dc.contributor.author | Moran, R | |
dc.contributor.author | Dolan, RJ | |
dc.contributor.author | Hauser, TU | |
dc.date.accessioned | 2023-12-20T10:07:01Z | |
dc.date.available | 2021-01-03 | |
dc.date.available | 2023-12-20T10:07:01Z | |
dc.date.issued | 2021-01-04 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/93139 | |
dc.description.abstract | An exploration-exploitation trade-off, the arbitration between sampling a lesser-known against a known rich option, is thought to be solved using computationally demanding exploration algorithms. Given known limitations in human cognitive resources, we hypothesised the presence of additional cheaper strategies. We examined for such heuristics in choice behaviour where we show this involves a value-free random exploration, that ignores all prior knowledge, and a novelty exploration that targets novel options alone. In a double-blind, placebo-controlled drug study, assessing contributions of dopamine (400 mg amisulpride) and noradrenaline (40 mg propranolol), we show that value-free random exploration is attenuated under the influence of propranolol, but not under amisulpride. Our findings demonstrate that humans deploy distinct computationally cheap exploration strategies and that value-free random exploration is under noradrenergic control. | en_US |
dc.language | eng | |
dc.publisher | eLife | en_US |
dc.relation.ispartof | Elife | |
dc.rights | This item is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject | dopamine | en_US |
dc.subject | exploration-exploitation | en_US |
dc.subject | human | en_US |
dc.subject | neuroscience | en_US |
dc.subject | noradrenaline | en_US |
dc.subject | Adult | en_US |
dc.subject | Choice Behavior | en_US |
dc.subject | Dopamine | en_US |
dc.subject | Double-Blind Method | en_US |
dc.subject | Exploratory Behavior | en_US |
dc.subject | Female | en_US |
dc.subject | Heuristics | en_US |
dc.subject | Humans | en_US |
dc.subject | Male | en_US |
dc.subject | Norepinephrine | en_US |
dc.subject | Young Adult | en_US |
dc.title | Human complex exploration strategies are enriched by noradrenaline-modulated heuristics. | en_US |
dc.type | Article | en_US |
dc.rights.holder | © 2021. The Authors. Published by eLife | |
dc.identifier.doi | 10.7554/eLife.59907 | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/33393461 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 10 | en_US |
dcterms.dateAccepted | 2021-01-03 | |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |
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Except where otherwise noted, this item's license is described as This item is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.