dc.contributor.author | Deserno, L | |
dc.contributor.author | Moran, R | |
dc.contributor.author | Michely, J | |
dc.contributor.author | Lee, Y | |
dc.contributor.author | Dayan, P | |
dc.contributor.author | Dolan, RJ | |
dc.date.accessioned | 2023-12-20T09:46:06Z | |
dc.date.available | 2021-12-08 | |
dc.date.available | 2023-12-20T09:46:06Z | |
dc.date.issued | 2021-12-09 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/93132 | |
dc.description.abstract | Dopamine is implicated in representing model-free (MF) reward prediction errors a as well as influencing model-based (MB) credit assignment and choice. Putative cooperative interactions between MB and MF systems include a guidance of MF credit assignment by MB inference. Here, we used a double-blind, placebo-controlled, within-subjects design to test an hypothesis that enhancing dopamine levels boosts the guidance of MF credit assignment by MB inference. In line with this, we found that levodopa enhanced guidance of MF credit assignment by MB inference, without impacting MF and MB influences directly. This drug effect correlated negatively with a dopamine-dependent change in purely MB credit assignment, possibly reflecting a trade-off between these two MB components of behavioural control. Our findings of a dopamine boost in MB inference guidance of MF learning highlight a novel DA influence on MB-MF cooperative interactions. | en_US |
dc.language | eng | |
dc.publisher | eLife | en_US |
dc.relation.ispartof | Elife | |
dc.rights | This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. | |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject | dopamine | en_US |
dc.subject | human | en_US |
dc.subject | model-free/model-based | en_US |
dc.subject | neuroscience | en_US |
dc.subject | reinforcement learning | en_US |
dc.subject | Adult | en_US |
dc.subject | Dopamine | en_US |
dc.subject | Double-Blind Method | en_US |
dc.subject | Female | en_US |
dc.subject | Humans | en_US |
dc.subject | Learning | en_US |
dc.subject | Male | en_US |
dc.subject | Models, Psychological | en_US |
dc.subject | Reinforcement, Psychology | en_US |
dc.subject | Reward | en_US |
dc.subject | Young Adult | en_US |
dc.title | Dopamine enhances model-free credit assignment through boosting of retrospective model-based inference. | en_US |
dc.type | Article | en_US |
dc.rights.holder | © 2023 The Author(s). Published by eLife | |
dc.identifier.doi | 10.7554/eLife.67778 | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/34882092 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 10 | en_US |
dcterms.dateAccepted | 2021-12-08 | |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |