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Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers.

dc.contributor.authorHoward, A
dc.contributor.authorBojko, J
dc.contributor.authorFlynn, B
dc.contributor.authorBowen, S
dc.contributor.authorJungwirth, U
dc.contributor.authorWalko, G
dc.date.accessioned2023-11-30T15:29:11Z
dc.date.available2022-07-25
dc.date.available2023-11-30T15:29:11Z
dc.date.issued2022-10
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/92542
dc.description.abstractSkin cancers are by far the most frequently diagnosed human cancers. The closely related transcriptional co-regulator proteins YAP and TAZ (WWTR1) have emerged as important drivers of tumour initiation, progression and metastasis in melanoma and non-melanoma skin cancers. YAP/TAZ serve as an essential signalling hub by integrating signals from multiple upstream pathways. In this review, we summarize the roles of YAP/TAZ in skin physiology and tumorigenesis and discuss recent efforts of therapeutic interventions that target YAP/TAZ in in both preclinical and clinical settings, as well as their prospects for use as skin cancer treatments.en_US
dc.format.extent1477 - 1499
dc.languageeng
dc.relation.ispartofExp Dermatol
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectHippo signallingen_US
dc.subjectbasal cell carcinomaen_US
dc.subjectepidermisen_US
dc.subjectmelanomaen_US
dc.subjectskin canceren_US
dc.subjectsquamous cell carcinomaen_US
dc.subjectAdaptor Proteins, Signal Transducingen_US
dc.subjectCell Transformation, Neoplasticen_US
dc.subjectHumansen_US
dc.subjectSkin Neoplasmsen_US
dc.subjectTrans-Activatorsen_US
dc.subjectTranscription Factorsen_US
dc.subjectTranscriptional Coactivator with PDZ-Binding Motif Proteinsen_US
dc.subjectYAP-Signaling Proteinsen_US
dc.titleTargeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers.en_US
dc.typeArticleen_US
dc.identifier.doi10.1111/exd.14655
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/35913427en_US
pubs.issue10en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume31en_US
dcterms.dateAccepted2022-07-25
qmul.funderTargeting YAP/TAZ as a novel therapeutic strategy in cutaneous squamous cell carcinoma.::Academy of Medical Sciencesen_US
qmul.funderTargeting YAP/TAZ as a novel therapeutic strategy in cutaneous squamous cell carcinoma.::Academy of Medical Sciencesen_US
qmul.funderTargeting YAP/TAZ as a novel therapeutic strategy in cutaneous squamous cell carcinoma.::Academy of Medical Sciencesen_US


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Attribution 3.0 United States
Except where otherwise noted, this item's license is described as Attribution 3.0 United States