dc.contributor.author | Garau, C | |
dc.contributor.author | Hayes, J | |
dc.contributor.author | Chiacchierini, G | |
dc.contributor.author | McCutcheon, JE | |
dc.contributor.author | Apergis-Schoute, J | |
dc.date.accessioned | 2023-11-07T14:52:14Z | |
dc.date.available | 2023-09-18 | |
dc.date.available | 2023-11-07T14:52:14Z | |
dc.date.issued | 2023-10-09 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/91767 | |
dc.description.abstract | Tyrosine hydroxylase (TH)-containing neurons of the dopamine (DA) cell group A13 are well positioned to impact known DA-related functions as their descending projections innervate target regions that regulate vigilance, sensory integration, and motor execution. Despite this connectivity, little is known regarding the functionality of A13-DA circuits. Using TH-specific loss-of-function methodology and techniques to monitor population activity in transgenic rats in vivo, we investigated the contribution of A13-DA neurons in reward and movement-related actions. Our work demonstrates a role for A13-DA neurons in grasping and handling of objects but not reward. A13-DA neurons responded strongly when animals grab and manipulate food items, whereas their inactivation or degeneration prevented animals from successfully doing so-a deficit partially attributed to a reduction in grip strength. By contrast, there was no relation between A13-DA activity and food-seeking behavior when animals were tested on a reward-based task that did not include a reaching/grasping response. Motivation for food was unaffected, as goal-directed behavior for food items was in general intact following A13 neuronal inactivation/degeneration. An anatomical investigation confirmed that A13-DA neurons project to the superior colliculus (SC) and also demonstrated a novel A13-DA projection to the reticular formation (RF). These results establish a functional role for A13-DA neurons in prehensile actions that are uncoupled from the motivational factors that contribute to the initiation of forelimb movements and help position A13-DA circuits into the functional framework regarding centrally located DA populations and their ability to coordinate movement. | en_US |
dc.language | eng | |
dc.relation.ispartof | Curr Biol | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | A13 | en_US |
dc.subject | dopamine | en_US |
dc.subject | grasping | en_US |
dc.subject | neural circuits | en_US |
dc.subject | reticular formation | en_US |
dc.subject | skilled forelimb movements | en_US |
dc.subject | superior colliculus | en_US |
dc.subject | zona incerta | en_US |
dc.title | Involvement of A13 dopaminergic neurons in prehensile movements but not reward in the rat. | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.cub.2023.09.044 | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/37816347 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
dcterms.dateAccepted | 2023-09-18 | |
qmul.funder | Prefrontal control of hypothalamic feeding circuits: Balancing executive control of eating::Wellcome Trust | en_US |