Osteocytes and Primary Cilia.
dc.contributor.author | Verbruggen, SW | |
dc.contributor.author | Sittichokechaiwut, A | |
dc.contributor.author | Reilly, GC | |
dc.date.accessioned | 2023-10-06T09:10:12Z | |
dc.date.available | 2023-08-25 | |
dc.date.available | 2023-10-06T09:10:12Z | |
dc.date.issued | 2023-09-08 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/91203 | |
dc.description.abstract | PURPOSE OF REVIEW: The purpose of this review is to provide a background on osteocytes and the primary cilium, discussing the role it plays in osteocyte mechanosensing. RECENT FINDINGS: Osteocytes are thought to be the primary mechanosensing cells in bone tissue, regulating bone adaptation in response to exercise, with the primary cilium suggested to be a key mechanosensing mechanism in bone. More recent work has suggested that, rather than being direct mechanosensors themselves, primary cilia in bone may instead form a key chemo-signalling nexus for processing mechanoregulated signalling pathways. Recent evidence suggests that pharmacologically induced lengthening of the primary cilium in osteocytes may potentiate greater mechanotransduction, rather than greater mechanosensing. While more research is required to delineate the specific osteocyte mechanobiological molecular mechanisms governed by the primary cilium, it is clear from the literature that the primary cilium has significant potential as a therapeutic target to treat mechanoregulated bone diseases, such as osteoporosis. | en_US |
dc.language | eng | |
dc.publisher | Springer Nature | en_US |
dc.relation.ispartof | Curr Osteoporos Rep | |
dc.rights | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject | Biomechanics | en_US |
dc.subject | Bone | en_US |
dc.subject | Mechanobiology | en_US |
dc.subject | Osteocyte | en_US |
dc.subject | Primary cilium | en_US |
dc.title | Osteocytes and Primary Cilia. | en_US |
dc.type | Article | en_US |
dc.rights.holder | © 2023, the Author(s). Published by Springer Nature | |
dc.identifier.doi | 10.1007/s11914-023-00819-1 | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/37682373 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
dcterms.dateAccepted | 2023-08-25 | |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.