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dc.contributor.authorHackett, Siobhán
dc.date.accessioned2015-09-29T14:06:50Z
dc.date.available2015-09-29T14:06:50Z
dc.date.issued2014-09
dc.identifier.citationHackett, S. 2014. Exploring the reactions of small rings. Queen Mary university of London.en_US
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/8965
dc.descriptionPhDen_US
dc.description.abstractSmall rings are frequently found in natural products as well as incorporated into drugs and agrochemicals in which they impart valuable properties on the biological activity of these compounds. Cyclopropanes are also extremely useful as reagents in organic synthesis, in particular as “umpolung” reagents, allowing access to products which would otherwise be more difficult to synthesise. This thesis will describe forays into the synthesis and further substitution of small rings as well as the iminium-catalysed ring-opening of cyclopropanes. The introduction will outline the uses and properties of cyclopropanes, and will also describe some of the more common ways for incorporating cyclopropanes into larger structures. This will include the Horner–Wadsworth–Emmons procedure which has previously been developed by the group. The second chapter describes efforts towards the iminium-catalysed nucleophilic ring-opening of cyclopropanes. This is followed by Chapter 3, in which the Horner–Wadsworth–Emmons methodology for the synthesis of the cyclopropanes used in Chapter 2 is investigated as a procedure for the synthesis of 4-membered heterocycles. Chapter 4 describes the development of a decarboxylative method for the protodecarboxylation of cyclopropanecarboxylic acids. This was developed as the first step towards decarboxylative cross-coupling of cyclopropanes. Decarboxylative cross-couplings have been extensively developed as environmentally friendly and facile alternatives to the current cross-coupling methods. In Chapter 5 the attempted development of a decarboxylative cross-coupling reaction of cyclopropanes is described. Conclusions and future work are outlined in Chapter 6, followed by the experimental details in Chapter 7.en_US
dc.description.sponsorshipQueen Mary University of London.en_US
dc.language.isoenen_US
dc.publisherQueen Mary University of Londonen_US
dc.subjectChemistryen_US
dc.subjectOrganic synthesisen_US
dc.subjectCyclopropanesen_US
dc.subjectSmall ringsen_US
dc.subjectHorner–Wadsworth–Emmons procedureen_US
dc.titleExploring the reactions of small rings.en_US
dc.typeThesisen_US
dc.rights.holderThe copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the author


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