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dc.contributor.authorBangash, Mansoor Nawaz
dc.date.accessioned2015-09-09T14:19:34Z
dc.date.available2015-09-09T14:19:34Z
dc.date.issued2015-02-16
dc.identifier.citationBangash, MN. 2015. Immune, microvascular and haemodynamic effects of dopexamine in rodent models of laparotomy & endotoxaemia. Queen Mary University of Londonen_US
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/8574
dc.descriptionPhDen_US
dc.description.abstractA growing body of evidence suggests that the potential exists to reduce morbidity and high mortality rates associated with major surgery in high-risk patients. Dopexamine is a dopamine analogue with agonist activity at β2-adrenoceptors and dopaminergic receptors that has been used to maintain tissue perfusion in critically ill and high-risk surgical patients with the aim of improving clinical outcomes. Postoperative complications occur more frequently in the presence of poor tissue microvascular flow and oxygenation, and dopexamine has been shown to improve these abnormalities. However, the effect of dopexamine on clinical outcomes is less clear, and the findings of randomized trials have proved inconsistent. These conflicting findings might be explained by dose-related differences in the hemodynamic and immunologic effects of dopexamine. The series of investigations that make up this thesis set out to explore the nature of any such dose-related effects and reveal potent anti-inflammatory effects of dopexamine in the absence of haemodynamic effects.en_US
dc.description.sponsorshipIntensive Care Young Investigator Award and a National Institute of Academic Anaesthesia RCoA/BJA Project Grant.en_US
dc.language.isoenen_US
dc.publisherQueen Mary University of Londonen_US
dc.subjectdopexamineen_US
dc.subjectendotoxaemiaen_US
dc.subjectlaparotomyen_US
dc.titleImmune, microvascular and haemodynamic effects of dopexamine in rodent models of laparotomy & endotoxaemiaen_US
dc.typeThesisen_US
dc.rights.holderThe copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the author


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    Theses Awarded by Queen Mary University of London

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