• Login
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    Role of oxidative stress in the balding dermal papilla 
    •   QMRO Home
    • Queen Mary University of London Theses
    • Theses
    • Role of oxidative stress in the balding dermal papilla
    •   QMRO Home
    • Queen Mary University of London Theses
    • Theses
    • Role of oxidative stress in the balding dermal papilla
    ‌
    ‌

    Browse

    All of QMROCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    ‌
    ‌

    Administrators only

    Login
    ‌
    ‌

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Role of oxidative stress in the balding dermal papilla

    View/Open
    Jamie Upton PhD.pdf (2.982Mb)
    Publisher
    Queen Mary University of London
    Metadata
    Show full item record
    Abstract
    The dermal papillae of the hair follicle control its growth, differentiation and apoptosis via a range of growth factors. These secreted growth factors are known to differ between those of non-balding scalp and those of balding scalp and can even differ in response to a common stimuli – androgen. In balding scalp androgen stimulates the secretion of negative growth factors, while in non-balding scalp androgen is found to exert little or no effect. Dermal papilla cells (DPCs) can be cultured in vitro, however those from balding scalp have been found to undergo premature senescence compared to those from non-balding scalp. A major cause of premature senescence is oxidative stress – the gradual accumulation of reactive oxygen species within the cell causing deleterious loss of function. Reactive oxygen species are known to be mediated in response to androgens and growth factors and in turn may affect growth factor signalling within the cell. Using low oxygen cell culture as a means of reducing oxidative stress, balding and non-balding DPCs were grown and characterised. It was confirmed that low oxygen culture could increase proliferation, delay senescence and reduce reactive oxygen species with both DPC types and that balding DPCs showed a higher sensitivity to oxidative stress. It was also found that secretions of growth factors by the balding DPCs in response to different oxygen conditions differed greatly to that of the occipital DPCs. Androgen, but not TGF-β was found to modulate DPC production of catalase, an antioxidant, under low oxygen conditions and this caused a reduction in reactive oxygen species in the balding DPCs. Balding DPCs also demonstrated an upregulation of the antioxidant total glutathione, however had a reduced fraction of the active reduced form of the molecule. In addition, it was shown for the first time 3 that under cell culture conditions balding DPCs express TGF-β receptors and it was shown that proliferation and migration of the balding DPCs could be affected by addition of exogenous TGF-β, highlighting a potential role for TGF-β as an autocrine growth factor in the balding dermal papilla.
    Authors
    Upton, Jamie
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/8478
    Collections
    • Theses [3600]
    Copyright statements
    The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the author
    Twitter iconFollow QMUL on Twitter
    Twitter iconFollow QM Research
    Online on twitter
    Facebook iconLike us on Facebook
    • Site Map
    • Privacy and cookies
    • Disclaimer
    • Accessibility
    • Contacts
    • Intranet
    • Current students

    Modern Slavery Statement

    Queen Mary University of London
    Mile End Road
    London E1 4NS
    Tel: +44 (0)20 7882 5555

    © Queen Mary University of London.