Characteristics, management, and outcomes of patients with left-sided infective endocarditis complicated by heart failure: a substudy of the ESC-EORP EURO-ENDO (European infective endocarditis) registry.
dc.contributor.author | Bohbot, Y | en_US |
dc.contributor.author | Habib, G | en_US |
dc.contributor.author | Laroche, C | en_US |
dc.contributor.author | Stöhr, E | en_US |
dc.contributor.author | Chirouze, C | en_US |
dc.contributor.author | Hernandez-Meneses, M | en_US |
dc.contributor.author | Melissopoulou, M | en_US |
dc.contributor.author | Mutlu, B | en_US |
dc.contributor.author | Scheggi, V | en_US |
dc.contributor.author | Branco, L | en_US |
dc.contributor.author | Olmos, C | en_US |
dc.contributor.author | Reyes, G | en_US |
dc.contributor.author | Pazdernik, M | en_US |
dc.contributor.author | Iung, B | en_US |
dc.contributor.author | Sow, R | en_US |
dc.contributor.author | Mirocevic, M | en_US |
dc.contributor.author | Lancellotti, P | en_US |
dc.contributor.author | Tribouilloy, C | en_US |
dc.contributor.author | EORP EURO-ENDO Registry Investigators Group | en_US |
dc.date.accessioned | 2022-09-27T14:10:39Z | |
dc.date.available | 2022-04-22 | en_US |
dc.date.issued | 2022-07 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/80791 | |
dc.description.abstract | AIMS: To evaluate the current management and survival of patients with left-sided infective endocarditis (IE) complicated by congestive heart failure (CHF) in the ESC-EORP European Endocarditis (EURO-ENDO) registry. METHODS AND RESULTS: Among the 3116 patients enrolled in this prospective registry, 2449 (mean age: 60 years, 69% male) with left-sided (native or prosthetic) IE were included in this study. Patients with CHF (n = 698, 28.5%) were older, with more comorbidity and more severe valvular damage (mitro-aortic involvement, vegetations >10 mm and severe regurgitation/new prosthesis dehiscence) than those without CHF (all p ≤ 0.019). Patients with CHF experienced higher 30-day and 1-year mortality than those without (20.5% vs. 9.0% and 36.1% vs. 19.3%, respectively) and CHF remained strongly associated with 30-day (odds ratio[OR] 2.37, 95% confidence interval [CI] [1.73-3.24; p < 0.001) and 1-year mortality (hazard ratio [HR] 1.69, 95% CI 1.39-2.05; p < 0.001) after adjustment for established outcome predictors, including early surgery, or after propensity matching for age, sex, and comorbidity (n = 618 [88.5%] for each group, both p < 0.001). Early surgery, performed on 49% of these patients with IE complicated by CHF, remained associated with a substantial reduction in 30-day mortality following multivariable analysis, after adjustment for age, sex, Charlson comorbidity index, cerebrovascular accident, Staphylococcus aureus IE, streptococcal IE, uncontrolled infection, vegetation size >10 mm, severe valvular regurgitation and/or new prosthetic dehiscence, perivalvular complication, and prosthetic IE (OR 0.22, 95% CI 0.12-0.38; p < 0.001) and in 1-year mortality (HR 0.29, 95% CI 0.20-0.41; p < 0.001). CONCLUSION: Congestive heart failure is common in left-sided IE and is associated with older age, greater comorbidity, more advanced lesions, and markedly higher 30-day and 1-year mortality. Early surgery is strongly associated with lower mortality but is performed on only approximately half of patients with CHF, mainly because of a surgical risk considered prohibitive. | en_US |
dc.format.extent | 1253 - 1265 | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Eur J Heart Fail | en_US |
dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs | |
dc.subject | Congestive heart failure | en_US |
dc.subject | EURO-ENDO | en_US |
dc.subject | Early surgery | en_US |
dc.subject | Infective endocarditis | en_US |
dc.subject | Outcome | en_US |
dc.subject | Survival | en_US |
dc.subject | Endocarditis | en_US |
dc.subject | Endocarditis, Bacterial | en_US |
dc.subject | Female | en_US |
dc.subject | Heart Failure | en_US |
dc.subject | Hospital Mortality | en_US |
dc.subject | Humans | en_US |
dc.subject | Male | en_US |
dc.subject | Middle Aged | en_US |
dc.subject | Prospective Studies | en_US |
dc.subject | Registries | en_US |
dc.subject | Retrospective Studies | en_US |
dc.title | Characteristics, management, and outcomes of patients with left-sided infective endocarditis complicated by heart failure: a substudy of the ESC-EORP EURO-ENDO (European infective endocarditis) registry. | en_US |
dc.type | Article | |
dc.identifier.doi | 10.1002/ejhf.2525 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/35508915 | en_US |
pubs.issue | 7 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 24 | en_US |
dcterms.dateAccepted | 2022-04-22 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |
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