Show simple item record

Ancient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinoderm

dc.contributor.authorTinoco, AB
dc.contributor.authorBarreiro-Iglesias, A
dc.contributor.authorYañez Guerra, LA
dc.contributor.authorDelroisse, J
dc.contributor.authorZhang, Y
dc.contributor.authorGunner, EF
dc.contributor.authorZampronio, CG
dc.contributor.authorJones, AM
dc.contributor.authorEgertová, M
dc.contributor.authorElphick, MR
dc.date.accessioned2021-09-16T12:47:25Z
dc.date.available2021-08-18
dc.date.available2021-09-16T12:47:25Z
dc.date.issued2021
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/74081
dc.description.abstractSulfakinin (SK)/cholecystokinin (CCK)-type neuropeptides regulate feeding and digestion in protostomes (e.g. insects) and chordates. Here, we characterised SK/CCK-type signalling for the first time in a non-chordate deuterostome – the starfish Asterias rubens (phylum Echinodermata). In this species, two neuropeptides (ArSK/CCK1, ArSK/CCK2) derived from the precursor protein ArSK/CCKP act as ligands for an SK/CCK-type receptor (ArSK/CCKR) and these peptides/proteins are expressed in the nervous system, digestive system, tube feet, and body wall. Furthermore, ArSK/CCK1 and ArSK/CCK2 cause dose-dependent contraction of cardiac stomach, tube foot, and apical muscle preparations in vitro, and injection of these neuropeptides in vivo triggers cardiac stomach retraction and inhibition of the onset of feeding in A. rubens. Thus, an evolutionarily ancient role of SK/CCK-type neuropeptides as inhibitory regulators of feeding-related processes in the Bilateria has been conserved in the unusual and unique context of the extra-oral feeding behaviour and pentaradial body plan of an echinoderm.en_US
dc.languageen
dc.publishereLife Sciences Publications, Ltden_US
dc.relation.ispartofeLife
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.titleAncient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinodermen_US
dc.typeArticleen_US
dc.rights.holder© 2021, Tinoco et al.
dc.identifier.doi10.7554/elife.65667
pubs.notesNot knownen_US
pubs.publication-statusPublished onlineen_US
pubs.volume10en_US
dcterms.dateAccepted2021-08-18
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
qmul.funderNeuropeptide function in a decentralised nervous system::Biotechnology and Biological Sciences Research Councilen_US
qmul.funderNeuropeptide function in a decentralised nervous system::Biotechnology and Biological Sciences Research Councilen_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Except where otherwise noted, this item's license is described as This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.