Lack of Causal Effects or Genetic Correlation between Restless Legs Syndrome and Parkinson's Disease.
dc.contributor.author | Estiar, MA | en_US |
dc.contributor.author | Senkevich, K | en_US |
dc.contributor.author | Yu, E | en_US |
dc.contributor.author | Varghaei, P | en_US |
dc.contributor.author | Krohn, L | en_US |
dc.contributor.author | Bandres-Ciga, S | en_US |
dc.contributor.author | Noyce, AJ | en_US |
dc.contributor.author | Rouleau, GA | en_US |
dc.contributor.author | Gan-Or, Z | en_US |
dc.date.accessioned | 2021-05-10T16:40:38Z | |
dc.date.available | 2021-04-26 | en_US |
dc.date.issued | 2021-05-11 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/71705 | |
dc.description.abstract | BACKGROUND: Epidemiological studies have reported an association between Parkinson's disease (PD) and restless legs syndrome. OBJECTIVES: We aimed to use genetic data to study whether these 2 disorders are causally linked or share genetic architecture. METHODS: We performed two-sample Mendelian randomization and linkage disequilibrium score regression using summary statistics from recent genome-wide meta-analyses of PD and restless legs syndrome. RESULTS: We found no evidence for a causal relationship between restless legs syndrome (as the exposure) and PD (as the outcome, inverse variance-weighted; b = -0.003, SE = 0.031, P = 0.916; F statistic = 217.5). Reverse Mendelian randomization also did not demonstrate any causal effect of PD on restless legs syndrome (inverse variance-weighted; b = -0.012, SE = 0.023, P = 0.592; F statistic = 191.7). Linkage disequilibrium score regression analysis demonstrated lack of genetic correlation between restless legs syndrome and PD (rg = -0.028, SE = 0.042, P = 0.507). CONCLUSIONS: There was no evidence for a causal relationship or genetic correlation between restless legs syndrome and PD. The associations observed in epidemiological studies could be attributed, in part, to confounding or nongenetic determinants. © 2021 International Parkinson and Movement Disorder Society. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Mov Disord | en_US |
dc.subject | Mendelian randomization | en_US |
dc.subject | Parkinson's disease | en_US |
dc.subject | genetic correlation | en_US |
dc.subject | linkage disequilibrium score regression | en_US |
dc.subject | restless legs syndrome | en_US |
dc.title | Lack of Causal Effects or Genetic Correlation between Restless Legs Syndrome and Parkinson's Disease. | en_US |
dc.type | Article | |
dc.identifier.doi | 10.1002/mds.28640 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/33974305 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
dcterms.dateAccepted | 2021-04-26 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |