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dc.contributor.authorVickaryous, N
dc.contributor.authorJitlal, M
dc.contributor.authorJacobs, BM
dc.contributor.authorMiddleton, R
dc.contributor.authorChandran, S
dc.contributor.authorMacDougall, NJJ
dc.contributor.authorGiovannoni, G
dc.contributor.authorDobson, R
dc.identifier.citationVickaryous N, Jitlal M, Jacobs BM, Middleton R, Chandran S, MacDougall NJJ, et al. (2020) Remote testing of vitamin D levels across the UK MS population—A case control study. PLoS ONE 15(12): e0241459.en_US
dc.description.abstractOBJECTIVE: The association between vitamin D deficiency and multiple sclerosis (MS) is well described. We set out to use remote sampling to ascertain vitamin D status and vitamin D supplementation in a cross-sectional study of people with MS across the UK. METHODS: People with MS and matched controls were recruited from across the UK. 1768 people with MS enrolled in the study; remote sampling kits were distributed to a subgroup. Dried blood spots (DBS) were used to assess serum 25(OH)D in people with MS and controls. RESULTS: 1768 MS participants completed the questionnaire; 388 MS participants and 309 controls provided biological samples. Serum 25(OH)D was higher in MS than controls (median 71nmol/L vs 49nmol/L). A higher proportion of MS participants than controls supplemented (72% vs 26%, p<0.001); people with MS supplemented at higher vD doses than controls (median 1600 vs 600 IU/day, p<0.001). People with MS who did not supplement had lower serum 25(OH)D levels than non-supplementing controls (median 38 nmol/L vs 44 nmol/L). Participants engaged well with remote sampling. CONCLUSIONS: The UK MS population have higher serum 25(OH)D than controls, mainly as a result of vitamin D supplementation. Remote sampling is a feasible way of carrying out large studies.en_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPLoS One
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.titleRemote testing of vitamin D levels across the UK MS population-A case control study.en_US
dc.rights.holder© 2020 Vickaryous et al.
pubs.notesNot knownen_US
pubs.publication-statusPublished onlineen_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US

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