Enhancement of the Biological and Mechanical Performances of Sintered Hydroxyapatite by Multiple Ions Doping
dc.contributor.author | Sprio, S | |
dc.contributor.author | Dapporto, M | |
dc.contributor.author | Preti, L | |
dc.contributor.author | Mazzoni, E | |
dc.contributor.author | Iaquinta, MR | |
dc.contributor.author | Martini, F | |
dc.contributor.author | Tognon, M | |
dc.contributor.author | Pugno, NM | |
dc.contributor.author | Restivo, E | |
dc.contributor.author | Visai, L | |
dc.contributor.author | Tampieri, A | |
dc.date.accessioned | 2020-11-12T13:24:02Z | |
dc.date.available | 2020-11-12T13:24:02Z | |
dc.date.issued | 2020-07-28 | |
dc.identifier.citation | Sprio, Simone et al. "Enhancement Of The Biological And Mechanical Performances Of Sintered Hydroxyapatite By Multiple Ions Doping". Frontiers In Materials, vol 7, 2020. Frontiers Media SA, doi:10.3389/fmats.2020.00224. Accessed 12 Nov 2020. | en_US |
dc.identifier.issn | 2296-8016 | |
dc.identifier.other | ARTN 224 | |
dc.identifier.other | ARTN 224 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/68242 | |
dc.description.abstract | In the present work, hydroxyapatite (HA) nanoparticles doped with Mg2+, Sr2+, and Zn2+ ions are developed by wet neutralization method and then sintered at 1,250°C to obtain bulk consolidated materials. Physicochemical and microstructural analyses show that the presence of doping ions in the HA structure induced the formation of βTCP as secondary phase, during the sintering process, and we found that this effect is depending on the stability of the various doping ions in the hydroxyapatite lattice itself. We also found that the formation of βTCP as secondary phase, in turn, confines the grain growth of HA induced by the high-temperature sintering process, thus leading to a strong increase of the flexural strength of the bulk materials, according to Hall-Petch-like law. Furthermore, we found that the doping ions enter also in the structure of the βTCP phase; besides the grain growth confinement, also the solubility and ion release ability of the final materials were enhanced. In addition to ameliorate the mechanical performance, the described phenomena also activate multiple biofunctionalities: (i) ability to upregulate various genes involved in the osteogenesis, as obtained by human adipose stem cells culture and evaluated by array technology; (ii) enhanced resistance to the adhesion and proliferation of Gram+ and Gram– bacterial strains. Hence, our results open a perspective for the use of sintered multiple ion-doped HA to develop ceramic biodevices, such as plates, screws, or other osteosynthesis media, with enhanced strength, osteointegrability, and the ability to prevent post-surgical infections. | en_US |
dc.publisher | Frontiers | en_US |
dc.relation.ispartof | FRONTIERS IN MATERIALS | |
dc.rights | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject | calcium phosphates | en_US |
dc.subject | ion doping | en_US |
dc.subject | osteogenic properties | en_US |
dc.subject | antibacterial properties | en_US |
dc.subject | mechanical properties | en_US |
dc.subject | magnesium | en_US |
dc.subject | strontium | en_US |
dc.subject | zinc | en_US |
dc.title | Enhancement of the Biological and Mechanical Performances of Sintered Hydroxyapatite by Multiple Ions Doping | en_US |
dc.type | Article | en_US |
dc.rights.holder | © 2020 Sprio, Dapporto, Preti, Mazzoni, Iaquinta, Martini, Tognon, Pugno, Restivo, Visai and Tampieri. | |
dc.identifier.doi | 10.3389/fmats.2020.00224 | |
pubs.author-url | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000561403900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6a | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 7 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |
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