dc.contributor.author | Zenner, D | en_US |
dc.contributor.author | Loutet, MG | en_US |
dc.contributor.author | Harris, R | en_US |
dc.contributor.author | Wilson, S | en_US |
dc.contributor.author | Ormerod, LP | en_US |
dc.date.accessioned | 2020-09-14T15:06:46Z | |
dc.date.available | 2017-04-20 | en_US |
dc.date.issued | 2017-07 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/67011 | |
dc.description.abstract | Approximately 72% of tuberculosis (TB) cases in England occur among non-UK born individuals, mostly as a result of reactivation of latent TB infection (LTBI). Programmatic LTBI screening is a key intervention of the TB strategy for England. This article reviews the results of a long-standing LTBI screening initiative in England.A retrospective cohort was created through probabilistic linkage between LTBI screening data and national TB case notifications. Screened persons were followed until they died, became a case, emigrated or until cohort-end. TB incidence rates and rate ratios (IRR) were calculated.97 out of 1820 individuals screened for LTBI were reported to have active TB. Crude incidence rates among LTBI-positive, treatment-naïve individuals were 4.1 and 2.3 per 100 person-years in the QuantiFERON and tuberculin skin test cohorts, respectively. Among the QuantiFERON cohort, Poisson regression showed that LTBI positivity (IRR 22.6, 95% CI 6.8-74.6) and no chemoprophylaxis increased the probability of becoming a TB case (IRR 0.17, 95% CI 0.05-0.6).We found high TB rates in LTBI-positive, treatment-naïve individuals and a strong association between no treatment and becoming a TB case, demonstrating feasibility and effectiveness of LTBI screening and providing important policy lessons for LTBI screening in England and beyond. | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Eur Respir J | en_US |
dc.rights | Attribution-NonCommercial 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/us/ | * |
dc.subject | Adult | en_US |
dc.subject | Databases, Factual | en_US |
dc.subject | England | en_US |
dc.subject | Female | en_US |
dc.subject | Humans | en_US |
dc.subject | Interferon-gamma | en_US |
dc.subject | Latent Tuberculosis | en_US |
dc.subject | Male | en_US |
dc.subject | Mass Screening | en_US |
dc.subject | Multivariate Analysis | en_US |
dc.subject | Regression Analysis | en_US |
dc.subject | Retrospective Studies | en_US |
dc.subject | Tuberculin Test | en_US |
dc.subject | Young Adult | en_US |
dc.title | Evaluating 17 years of latent tuberculosis infection screening in north-west England: a retrospective cohort study of reactivation. | en_US |
dc.type | Article | |
dc.identifier.doi | 10.1183/13993003.02505-2016 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/28751410 | en_US |
pubs.issue | 1 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 50 | en_US |
dcterms.dateAccepted | 2017-04-20 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |