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dc.contributor.authorVadgama, Pen_US
dc.date.accessioned2020-06-18T09:13:13Z
dc.date.available2020-05-31en_US
dc.date.issued2020-06-02en_US
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/65066
dc.description.abstractThe disruptive action of an acute or critical illness is frequently manifest through rapid biochemical changes that may require continuous monitoring. Within these changes, resides trend information of predictive value, including responsiveness to therapy. In contrast to physical variables, biochemical parameters monitored on a continuous basis are a largely untapped resource because of the lack of clinically usable monitoring systems. This is despite the huge testing repertoire opening up in recent years in relation to discrete biochemical measurements. Electrochemical sensors offer one of the few routes to obtaining continuous readout and, moreover, as implantable devices information referable to specific tissue locations. This review focuses on new biological insights that have been secured through in vivo electrochemical sensors. In addition, the challenges of operating in a reactive, biological, sample matrix are highlighted. Specific attention is given to the choreographed host rejection response, as evidenced in blood and tissue, and how this limits both sensor life time and reliability of operation. Examples will be based around ion, O2, glucose, and lactate sensors, because of the fundamental importance of this group to acute health care.en_US
dc.languageengen_US
dc.relation.ispartofSensors (Basel)en_US
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectO2en_US
dc.subjectforeign body reactionen_US
dc.subjectglucoseen_US
dc.subjection selective electrodesen_US
dc.subjectlactateen_US
dc.subjectmetabolite sensorsen_US
dc.subjectsensor biocompatibilityen_US
dc.titleMonitoring with In Vivo Electrochemical Sensors: Navigating the Complexities of Blood and Tissue Reactivity.en_US
dc.typeArticle
dc.rights.holder© The Author(s) 2020.
dc.identifier.doi10.3390/s20113149en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/32498360en_US
pubs.issue11en_US
pubs.notesNot knownen_US
pubs.publication-statusPublished onlineen_US
pubs.volume20en_US
dcterms.dateAccepted2020-05-31en_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
qmul.funderESPRIT::Engineering and Physical Sciences Research Councilen_US
rioxxterms.funder.project483cf8e1-88a1-4b8b-aecb-8402672d45f8en_US


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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Except where otherwise noted, this item's license is described as This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited