dc.contributor.author | Petersen, S | |
dc.contributor.author | Munroe, P | |
dc.contributor.author | Cooper, J | |
dc.contributor.author | Khanji, M | |
dc.contributor.author | Raisi-Estabragh, Z | |
dc.date.accessioned | 2020-06-09T13:39:20Z | |
dc.date.available | 2020-05-15 | |
dc.date.available | 2020-06-09T13:39:20Z | |
dc.date.issued | 2020-05-29 | |
dc.identifier.citation | Raisi-Estabragh Z, Cooper J, Judge R, Khanji MY, Munroe PB, Cooper C, et al. (2020) Age, sex and disease-specific associations between resting heart rate and cardiovascular mortality in the UK BIOBANK. PLoS ONE 15(5): e0233898. https://doi.org/10.1371/journal.pone.0233898 | en_US |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/64752 | |
dc.description.abstract | OBJECTIVE: To define the sex, age, and disease-specific associations of resting heart rate (RHR) with cardiovascular and mortality outcomes in 502,534 individuals from the UK Biobank over 7-12 years of prospective follow-up. METHODS: The main outcomes were all-cause, cardiovascular, and ischaemic heart disease mortality. Additional outcomes included incident acute myocardial infarction (AMI), fatal AMI, and cancer mortality. We considered a wide range of confounders and the effects of competing hazards. Results are reported as hazard ratios (HR) for all-cause mortality and sub-distribution hazard ratios (SHR) for other outcomes with corresponding 95% confidence intervals (CI) per 10bpm increment of RHR. RESULTS: In men, for every 10bpm increase of RHR there was 22% (HR 1.22, CI 1.20 to 1.24, p = 3×10-123) greater hazard of all-cause and 17% (SHR 1.17, CI 1.13 to 1.21, p = 5.6×10-18) greater hazard of cardiovascular mortality; for women, corresponding figures were 19% (HR 1.19, CI 1.16 to 1.22, p = 8.9×10-45) and 14% (SHR 1.14, CI 1.07 to 1.22, p = 0.00008). Associations between RHR and ischaemic outcomes were of greater magnitude amongst men than women, but with similar magnitude of association for non-cardiovascular cancer mortality [men (SHR 1.18, CI 1.15-1.21, p = 5.2×10-46); women 15% (SHR 1.15, CI 1.11-1.18, p = 3.1×10-18)]. Associations with all-cause, incident AMI, and cancer mortality were of greater magnitude at younger than older ages. CONCLUSIONS: RHR is an independent predictor of mortality, with variation by sex, age, and disease. Ischaemic disease appeared a more important driver of this relationship in men, and associations were more pronounced at younger ages. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Public Library of Science (PLoS) | en_US |
dc.relation.ispartof | PLoS One | |
dc.rights | Creative Commons Attribution License | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Age, sex and disease-specific associations between resting heart rate and cardiovascular mortality in the UK BIOBANK | en_US |
dc.type | Article | en_US |
dc.rights.holder | © 2020 Raisi-Estabragh et al. | |
dc.identifier.doi | https://doi.org/10.1371/journal.pone.0233898 | |
pubs.notes | Not known | en_US |
pubs.publication-status | Accepted | en_US |
dcterms.dateAccepted | 2020-05-15 | |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |
qmul.funder | NIHR BRC at Barts::National Institute of Health Research | en_US |
qmul.funder | NIHR BRC at Barts::National Institute of Health Research | en_US |
qmul.funder | NIHR BRC at Barts::National Institute of Health Research | en_US |