Recurrent acquisition of cytosine methyltransferases into eukaryotic retrotransposons
dc.contributor.author | de Mendoza, A | |
dc.contributor.author | Bonnet, A | |
dc.contributor.author | Vargas-Landin, DB | |
dc.contributor.author | Ji, N | |
dc.contributor.author | Hong, F | |
dc.contributor.author | Yang, F | |
dc.contributor.author | Li, L | |
dc.contributor.author | Hori, K | |
dc.contributor.author | Pflueger, J | |
dc.contributor.author | Buckberry, S | |
dc.contributor.author | Ohta, H | |
dc.contributor.author | Rosic, N | |
dc.contributor.author | Lesage, P | |
dc.contributor.author | Lin, S | |
dc.contributor.author | Lister, R | |
dc.date.accessioned | 2020-06-01T13:25:53Z | |
dc.date.available | 2018-03-07 | |
dc.date.available | 2020-06-01T13:25:53Z | |
dc.date.issued | 2018-04-09 | |
dc.identifier.citation | de Mendoza, Alex et al. "Recurrent Acquisition Of Cytosine Methyltransferases Into Eukaryotic Retrotransposons". Nature Communications, vol 9, no. 1, 2018. Springer Science And Business Media LLC, doi:10.1038/s41467-018-03724-9. Accessed 1 June 2020. | en_US |
dc.identifier.issn | 2041-1723 | |
dc.identifier.other | ARTN 1341 | |
dc.identifier.other | ARTN 1341 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/64526 | |
dc.description.abstract | Transposable elements are in a constant arms race with the silencing mechanisms of their host genomes. One silencing mechanism commonly used by many eukaryotes is dependent on cytosine methylation, a covalent modification of DNA deposited by C5 cytosine methyltransferases (DNMTs). Here, we report how two distantly related eukaryotic lineages, dinoflagellates and charophytes, have independently incorporated DNMTs into the coding regions of distinct retrotransposon classes. Concomitantly, we show that dinoflagellates of the genus Symbiodinium have evolved cytosine methylation patterns unlike any other eukaryote, with most of the genome methylated at CG dinucleotides. Finally, we demonstrate the ability of retrotransposon DNMTs to methylate CGs de novo, suggesting that retrotransposons could self-methylate retrotranscribed DNA. Together, this is an example of how retrotransposons incorporate host-derived genes involved in DNA methylation. In some cases, this event could have implications for the composition and regulation of the host epigenomic environment. | en_US |
dc.publisher | Nature | en_US |
dc.relation.ispartof | NATURE COMMUNICATIONS | |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.title | Recurrent acquisition of cytosine methyltransferases into eukaryotic retrotransposons | en_US |
dc.type | Article | en_US |
dc.rights.holder | © 2018 The Author(s) | |
dc.identifier.doi | 10.1038/s41467-018-03724-9 | |
pubs.author-url | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000429498100003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6a | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 9 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |
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