dc.contributor.author | Sequeira, I | |
dc.contributor.author | Watt, FM | |
dc.date.accessioned | 2020-05-19T07:44:23Z | |
dc.date.available | 2019-03-13 | |
dc.date.available | 2020-05-19T07:44:23Z | |
dc.date.issued | 2019-03-23 | |
dc.identifier.citation | nês Sequeira and Fiona M. Watt (2019). The role of keratins in modulating carcinogenesis via communication with cells of the immune system. Cell Stress 3(4): 136-138. doi: 10.15698/cst2019.04.184 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/64178 | |
dc.description.abstract | Keratins are intermediate filament proteins expressed by epithelial cells and provide mechanical support for diverse epithelia. In our recent study (Sequeira et al., Nat Comm 9(1):3437), we analysed the role of keratin 76 (Krt76) in inflammation and cancer. Krt76 is expressed throughout embryonic development in the differentiated epithelial layers of a subset of stratified epithelia including tongue, palate and stomach. It is significantly downregulated in human oral squamous cell carcinoma (OSCC), correlating strongly with poor prognosis. We have shown that Krt76-/- mice exhibit systemic inflammation with increased levels of circulating B cells, regulatory T cells and effector T cells. When mice are given a chemical carcinogen in the drinking water, tongue and gastric cancer formation is accelerated in Krt76-/- mutant mice. Our data suggest that the increased tumour susceptibility of Krt76-/- mice is in part due to the enhanced accumulation of regulatory T cells in the tumour microenvironment. Our results support the notion that keratins, in addition to their function as cytoskeletal components, regulate immunity and affect tumour susceptibility of epithelial cells. | en_US |
dc.format.extent | 136 - 138 | |
dc.language.iso | en | en_US |
dc.publisher | Shared Science Publishers OG | en_US |
dc.relation.ispartof | Cell Stress | |
dc.rights | Creative Commons Attribution (CC BY) license | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | The role of keratins in modulating carcinogenesis via communication with cells of the immune system | en_US |
dc.type | Article | en_US |
dc.rights.holder | © 2019 Sequeira and Watt. | |
dc.identifier.doi | 10.15698/cst2019.04.184 | |
pubs.issue | 4 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 3 | en_US |
dcterms.dateAccepted | 2019-03-13 | |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |