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dc.contributor.authorArias-Bujanda, N
dc.contributor.authorRegueira-Iglesias, A
dc.contributor.authorBalsa-Castro, C
dc.contributor.authorNibali, L
dc.contributor.authorDonos, N
dc.contributor.authorTomas, I
dc.date.accessioned2020-04-28T15:50:54Z
dc.date.available2019-08-21
dc.date.available2020-04-28T15:50:54Z
dc.date.issued2019-08-24
dc.identifier.citationArias‐Bujanda, N, Regueira‐Iglesias, A, Balsa‐Castro, C, Nibali, L, Donos, N, Tomás, I. Accuracy of single molecular biomarkers in gingival crevicular fluid for the diagnosis of periodontitis: A systematic review and meta‐analysis. J Clin Periodontol. 2019; 46: 1166– 1182. https://doi.org/10.1111/jcpe.13188en_US
dc.identifier.issn0303-6979
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/63798
dc.descriptionThis is the peer reviewed version of the following article: Arias‐Bujanda, N, Regueira‐Iglesias, A, Balsa‐Castro, C, Nibali, L, Donos, N, Tomás, I. Accuracy of single molecular biomarkers in gingival crevicular fluid for the diagnosis of periodontitis: A systematic review and meta‐analysis. J Clin Periodontol. 2019; 46: 1166– 1182. https://doi.org/10.1111/jcpe.13188, which has been published in final form at https://doi.org/10.1111/jcpe.13188. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versionsen_US
dc.description.abstractAbstract Aim To analyse, by means of a meta‐analytical approach, the diagnostic accuracy of molecular biomarkers in gingival crevicular fluid (GCF) for the detection of periodontitis in systemically healthy subjects. Material and Methods Studies on GCF molecular biomarkers providing a binary classification table (or sensitivity and specificity values and group sample sizes) in individuals with clinically diagnosed periodontitis were considered eligible. The search was performed using six electronic databases. The methodological quality of studies was assessed through the tool Quality Assessment of Diagnostic Studies. Meta‐analyses were performed using the Hierarchical Summary Receiver Operating Characteristic, which adjusts classification data using random effects logistic regression. Results The included papers identified 36 potential biomarkers for the detection of periodontitis and for four of them meta‐analyses were performed. The median sensitivity and specificity were for MMP8, 76.7% and 92.0%; for elastase, 74.6% and 81.1%; for cathepsin, 72.8% and 67.3%, respectively. The worst estimates of sensitivity and specificity were for trypsin (71.3% and 66.1%, respectively). Conclusions MMP8 showed good sensitivity and excellent specificity, which resulted in this biomarker being clinically the most useful or effective for the diagnosis of periodontitis in systemically healthy subjects, regardless of smoking conditionen_US
dc.description.sponsorshipInstituto de Salud Carlos III FEDER. Grant Number: ISCIII/PI17/01722 Consellería de Cultura, Educación e Ordenación Universitaria da Xunta de Galicia. Grant Numbers: ED431B 2017/029, ED481A‐2017en_US
dc.format.extent1166 - 1182
dc.language.isoenen_US
dc.publisherWiley Onlineen_US
dc.relation.ispartofJOURNAL OF CLINICAL PERIODONTOLOGY
dc.rights"This is the peer reviewed version of the following article: Arias‐Bujanda, N, Regueira‐Iglesias, A, Balsa‐Castro, C, Nibali, L, Donos, N, Tomás, I. Accuracy of single molecular biomarkers in gingival crevicular fluid for the diagnosis of periodontitis: A systematic review and meta‐analysis. J Clin Periodontol. 2019; 46: 1166– 1182. https://doi.org/10.1111/jcpe.13188 which has been published in final form at doi:  https://doi.org/10.1111/jcpe.13188 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."
dc.subjectdiagnostic accuracyen_US
dc.subjectgingival crevicular fluiden_US
dc.subjectmeta-analysisen_US
dc.subjectmolecular biomarkersen_US
dc.subjectperiodontitisen_US
dc.subjectpredictive valuesen_US
dc.subjectprevalenceen_US
dc.subjectsensitivityen_US
dc.subjectspecificityen_US
dc.subjectsystematic reviewen_US
dc.titleAccuracy of single molecular biomarkers in gingival crevicular fluid for the diagnosis of periodontitis: A systematic review and meta-analysisen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/jcpe.13188
pubs.author-urlhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000490725600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6aen_US
pubs.issue12en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume46en_US
dcterms.dateAccepted2019-08-21
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US


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