dc.contributor.author | Halai, H | |
dc.contributor.author | Somani, C | |
dc.contributor.author | Donos, N | |
dc.contributor.author | Nibali, L | |
dc.date.accessioned | 2020-04-23T10:29:27Z | |
dc.date.available | 2019-08-05 | |
dc.date.available | 2020-04-23T10:29:27Z | |
dc.date.issued | 2019-10-18 | |
dc.identifier.citation | Halai, H., Somani, C., Donos, N. et al. Periodontal status of children with primary immunodeficiencies: a systematic review. Clin Oral Invest (2019). https://doi.org/10.1007/s00784-019-03055-z | en_US |
dc.identifier.issn | 1432-6981 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/63719 | |
dc.description.abstract | Objective The aim of this systematic review was to appraise the existing literature on periodontal disease in children affected by
different types of neutrophil-associated primary immunodeficiencies (PIDs).
Methods A PRESS-validated search strategy was developed to search through databases MEDLINE, EMBASE, Cochrane
Central Register of Controlled Trials, LILACS, Google Scholar and Open Grey. All included studies were assessed for methodological quality and risk of bias.
Results One hundred eighteen articles reporting on 160 PID patients were included for qualitative analysis. The majority (70%)
were individual case reports. Clinical and radiographic manifestations of the periodontal disease included poor oral hygiene,
generalised alveolar bone loss, severe gingival inflammation, increased pocket depths, tooth mobility and gingival recession. For
most studies, the primary intervention was periodontal treatment in the form of scaling and root planing or dental extractions.
Stabilisation of the periodontal condition varied between different PIDs. In severe congenital neutropenia (SCN), 61% of cases
reported stabilisation of the periodontal condition, while for all other PIDs, ‘stability’ was reported in less than 43% of cases.
Conclusion The published literature suggests that patients with PIDs can present with severe periodontitis and that conventional
treatment approaches have limited benefits. | en_US |
dc.description.sponsorship | This article was made open access with the support of King’s College London | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer Nature | en_US |
dc.relation.ispartof | CLINICAL ORAL INVESTIGATIONS | |
dc.rights | CC-BY | * |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject | Immune defects | en_US |
dc.subject | Inflammatory diseases | en_US |
dc.subject | Paediatrics | en_US |
dc.subject | Periodontium | en_US |
dc.subject | Therapies | en_US |
dc.title | Periodontal status of children with primary immunodeficiencies: a systematic review | en_US |
dc.type | Article | en_US |
dc.rights.holder | 2019. The authors | |
dc.identifier.doi | 10.1007/s00784-019-03055-z | |
pubs.author-url | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000491392700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6a | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
dcterms.dateAccepted | 2019-08-05 | |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |